IL12A, interleukin 12A, 3592

N. diseases: 261; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis
0.640 Biomarker disease BEFREE Our data revealed that TLR stimulation of PBC (n = 17) and pSS monocytes (n = 6) resulted in significant induction of IL12A mRNA (p < 0.05, p < 0.01, respectively) compared to PSC monocytes (n = 13) and at similar levels to HC monocytes (n = 8). 30119881 2018
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis
0.640 GeneticVariation disease GWASCAT A genome-wide association study identifies six novel risk loci for primary biliary cholangitis. 28425483 2017
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis
0.640 Biomarker disease BEFREE In addition, the risk alleles of the 2 SNPs were significantly associated with down-regulation of SCHIP1, a celiac disease susceptible gene, 91.5 kb upstream of IL12A.These results not only demonstrated that IL12A is associated with PBC in the Chinese Han population but also identified a potential mechanism for its involvement in the pathogenesis of PBC. 27175695 2016
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis
0.640 GeneticVariation disease BEFREE Here, we performed an association analysis between IL12A, IL12RB, and signal transducer and activator of transcription 4 (STAT4) genetic variations and susceptibility to PBC. 24648611 2014
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis
0.640 GeneticVariation disease GWASDB Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. 22961000 2012
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis
0.640 Biomarker disease CTD_human Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. 20639880 2010
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis
0.640 GeneticVariation disease BEFREE Fine-mapping analysis showed that a five-allele haplotype in the 3' flank of IL12A was significantly associated with primary biliary cirrhosis (P=1.15x10(-34)). 19458352 2009
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis
0.640 SusceptibilityMutation disease ORPHANET