IL12A, interleukin 12A, 3592

N. diseases: 261; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.640 Biomarker disease BEFREE Our data revealed that TLR stimulation of PBC (n = 17) and pSS monocytes (n = 6) resulted in significant induction of IL12A mRNA (p < 0.05, p < 0.01, respectively) compared to PSC monocytes (n = 13) and at similar levels to HC monocytes (n = 8). 30119881 2018
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.640 GeneticVariation disease GWASCAT A genome-wide association study identifies six novel risk loci for primary biliary cholangitis. 28425483 2017
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.640 Biomarker disease BEFREE In addition, the risk alleles of the 2 SNPs were significantly associated with down-regulation of SCHIP1, a celiac disease susceptible gene, 91.5 kb upstream of IL12A.These results not only demonstrated that IL12A is associated with PBC in the Chinese Han population but also identified a potential mechanism for its involvement in the pathogenesis of PBC. 27175695 2016
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.640 GeneticVariation disease BEFREE Here, we performed an association analysis between IL12A, IL12RB, and signal transducer and activator of transcription 4 (STAT4) genetic variations and susceptibility to PBC. 24648611 2014
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.640 GeneticVariation disease GWASDB Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. 22961000 2012
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.640 Biomarker disease CTD_human Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. 20639880 2010
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.640 GeneticVariation disease BEFREE Fine-mapping analysis showed that a five-allele haplotype in the 3' flank of IL12A was significantly associated with primary biliary cirrhosis (P=1.15x10(-34)). 19458352 2009
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.640 SusceptibilityMutation disease ORPHANET
CUI: C0023892
Disease: Biliary cirrhosis
Biliary cirrhosis 		0.400 Biomarker disease CTD_human Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. 20639880 2010
CUI: C0023892
Disease: Biliary cirrhosis
Biliary cirrhosis 		0.400 Biomarker disease HPO
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.330 Biomarker disease BEFREE Rapamycin significantly altered the expression of several genes linked to Sjögren's syndrome pathogenesis, including major histocompatibility complex II, TNF-α, IFN-γ, and IL-12a, as well as Akt3, an effector of autophagy. 28122086 2017
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.330 Biomarker disease BEFREE Regarding the non-HLA genes, in addition to IL-23R, previously reported in our population; IL12A, described in other populations, was found to be a BD susceptibility factor also in Spaniards; finally, a new associated locus was found in the JRKL/CNTN5 region. 27548383 2016
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.330 Biomarker disease BEFREE Genome-wide association study in an admixed case series reveals IL12A as a new candidate in Behçet disease. 25799145 2015
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.330 SusceptibilityMutation disease ORPHANET Genome-wide association study in an admixed case series reveals IL12A as a new candidate in Behçet disease. 25799145 2015
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.330 Biomarker disease BEFREE Of particular relevance, was the significant association of SS with additional immune-related genes including IL12A, BLK, and CXCR5. 24657515 2014
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.330 Biomarker disease CTD_human Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. 24097067 2013
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.330 AlteredExpression disease BEFREE Moreover, the levels of IL-12 p35 mRNA in BD lesions were also not significantly different from the levels in normal control skin. 18205865 2008
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome 		0.330 AlteredExpression disease LHGDN Rates of infiltration by macrophages and dendritic cells and expression of interleukin-18 and interleukin-12 in the chronic inflammatory lesions of Sjögren's syndrome: correlation with certain features of immune hyperactivity and factors associated with high risk of lymphoma development. 18050195 2007
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.320 Biomarker disease CTD_human Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. 24076602 2013
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.320 GeneticVariation disease BEFREE Cytokine and cytokine receptor genes, including IL2RA, IL7R and IL12A, are known risk factors for multiple sclerosis (MS). 21716315 2012
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.320 GeneticVariation disease BEFREE It could be suggested that the genetic variation in IL-12 A/C (-1188) and IFN-gamma A/T (+874) cytokine genes could be risk factors for MS patients. 19543959 2009
CUI: C0086981
Disease: Sicca Syndrome
Sicca Syndrome 		0.300 Biomarker disease CTD_human Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. 24097067 2013
CUI: C0751324
Disease: Multiple Sclerosis, Acute Fulminating
Multiple Sclerosis, Acute Fulminating 		0.300 Biomarker disease CTD_human Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. 24076602 2013
CUI: C0238065
Disease: Secondary Biliary Cholangitis
Secondary Biliary Cholangitis 		0.300 Biomarker disease CTD_human Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. 20639880 2010
CUI: C4551595
Disease: Biliary Cirrhosis, Primary, 1
Biliary Cirrhosis, Primary, 1 		0.300 Biomarker disease CTD_human Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. 20639880 2010