|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Psoriasis and psoriatic arthritis fall into this disease spectrum, with the largest region of susceptibility coming from the MHC (most likely HLA-C, ie, C*06:02 although additional influences are also being implicated), and most of the other genetic susceptibility coming from genes involved in cytokine production, specifically genes in the Th17 pathway (IL-12B, IL-23A and IL-23R, the latter, like in AS, not seen in Asians), genes in the nuclear factor κB pathway (TNFAIP3 and TNIP1) and genes in the Th2 pathway (IL-4 and IL-13).
|
21339218 |
2011 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A multitiered genetic association study of 25 215 single-nucleotide polymorphisms (SNPs) in three case-control sample sets (1446 patients and 1432 controls) identified three IL13-linked SNPs (rs1800925, rs20541 and rs848) associated with psoriasis.
|
18075513 |
2008 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Although functional variants remain to be identified, we speculate that genetic variants at the IL4/IL13 locus contribute to the Th1 bias that is characteristic of psoriasis, that Th1-derived IFN-gamma supports expansion of IL-17+ T cells through APC-derived IL-23 and that negative regulation of inflammatory signaling through the NF-kappaB axis is impaired because of genetic variants of TNFAIP3 and TNIP1.
|
19262574 |
2009 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
As interleukin-13 is a pleiotropic immunoregulatory cytokine with a variety of effects on different cell types, including monocytes, B lymphocytes, mast cells, and keratinocytes, we suggest, based on our results, that the interleukin-13 receptor possibly plays an important part in the early inflammatory process of psoriasis; however, its function is lost in the psoriatic keratinocytes.
|
12445201 |
2002 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Association analyses identify six new psoriasis susceptibility loci in the Chinese population.
|
20953187 |
2010 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Association with psoriasis and psoriatic arthritis has been found in TNFAIP3 and TNFIP1, ubiquitin ligases in the NF-kappaB pathway, and IL13, a Th2 cytokine.
|
20415816 |
2010 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Atopic Dermatitis Is an IL-13-Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis.
|
30641038 |
2019 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Evidence for an association between EBV-negative cHL and rs20541 (5q31, IL13: OR = 1.53, 95% CI = 1.32 to 1.76, P = 5.4 x 10(-9)), a variant previously linked to psoriasis and asthma, was observed; however, the evidence for replication was less clear.
|
22286212 |
2012 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
|
26626624 |
2015 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.
|
25903422 |
2015 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Here, we investigated the distribution of type 2 cells and the source of IL-4 and IL-13 in skin and blood of AD relative to psoriasis.
|
28743611 |
2017 |
|
Psoriasis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
However, there was no significant difference in IL-13 gene expression in the skin of patients with psoriasis (n = 10) and that of healthy control subjects.
|
9328132 |
1997 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, two loci show strong evidence for association with PsA but not psoriasis: HLA-B27 and the IL-13 gene locus.
|
22532288 |
2012 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our comparison of a stratified population with type I psoriasis (n = 155) and healthy controls (N = 197) is the first to reveal a relationship between the CLMN, FBXL19, CCL4L, C17orf51, TYK2, IL13, SLC22A4, CDKAL1, and HLA-B/MICA genes.
|
26613086 |
2015 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms within the gene encoding IL-13, a Th2 cytokine, also confer risk for psoriasis.
|
18830267 |
2009 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, the results of multiple well-powered genome-wide association studies have identified several additional loci outside the major histocompatibility complex region associated with psoriasis risk, including three genes involved in interleukin (IL)-23 signaling (IL-23R, IL-23A, IL-12B), two genes that regulate nuclear factor-kappaB signaling (TNIP1, TNFAIP3), and two genes involved in the modulation of T-helper type 2 immune responses (IL-4, IL-13).
|
20480402 |
2010 |
|
Psoriasis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Similarly, association of the 5q31 gene region encompassing the IL13 gene has been reported with PsA but not psoriasis by one group, but this awaits confirmation in other series.
|
20875338 |
2010 |
|
Psoriasis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The authors genotyped three groups of Caucasians: those with PsA, those with psoriasis without arthritis (PsC) and healthy controls for the rs20541 and rs848 IL13 single nucleotide polymorphisms (SNPs).
|
21613309 |
2011 |