Asthma
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
We found a significant enhancement of both IL-13 transcripts and secreted proteins in the allergen-challenged BAL compared with the saline-challenged control sites of asthmatic and rhinitic patients.
|
7650396 |
1995 |
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We evaluated IL-1 alpha, -2, -4, -5, -6, -13, and granulocyte-macrophage colony-stimulating factor (GM-CSF), and interferon-gamma (IFN-gamma). mRNAs for IL-1 alpha, -2, -4, -5, and IFN-gamma were detected in all of the atopic subjects; mRNAs for IL-6 and GM-CSF were found in five asthmatics; and mRNA for IL-13 was found in one patient only.
|
9087947 |
1997 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our results suggest that when activated by IL-4 and IL-13, different subsets of lung fibroblasts may act as effector cells not only in the pathogenesis of asthma but also in lung remodeling processes.
|
9593769 |
1998 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Through this peculiar cytokine pattern and the IL-4/IL-13-dependent activities, these cells could act as effector cells in the pathogenesis of asthma, triggering and maintaining the recruitment, homing and activation of bone marrow-derived inflammatory cells, and playing a role in the remodeling process of the airways.
|
9796908 |
1998 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Selective neutralization of IL-13, a cytokine related to IL-4 that also binds to the alpha chain of the IL-4 receptor, ameliorated the asthma phenotype, including airway hyperresponsiveness, eosinophil recruitment, and mucus overproduction.
|
9856950 |
1998 |
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Our analysis revealed that without any overt stimulation, mRNA transcripts for interleukin (IL)-5 and IL-13 were expressed by asthmatic but not normal bronchial tissue.
|
9870929 |
1999 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
IL-4 and IL-13 are T(H)2 cytokines with numerous activities that contribute to allergic inflammation and asthma.
|
10550746 |
1999 |
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A novel variant of human IL-13, Gln110Arg, on chromosome 5q31, associated with asthma rather than IgE levels in case-control populations from Britain and Japan [peak odds ratio (OR) = 2.31, 95% CI 1.33-4.00]; the variant also predicted asthma and higher serum IL-13 levels in a general, Japanese paediatric population.
|
10699178 |
2000 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
When both IL-4 and IL-5 were neutralized in this system, AHR was still induced, suggesting that influenza-induced cytokines such as IL-13, or mechanisms unrelated to cytokines, might be responsible for the development of AHR.
|
10975869 |
2000 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
They also demonstrate that IL-13 causes emphysema via a MMP- and cathepsin-dependent mechanism(s) and highlight common mechanisms that may underlie COPD and asthma.
|
11067861 |
2000 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The IL-13 gene is located on chromosome 5q31, one of the major loci to be linked to asthma susceptibility, and amongst a cluster of genes which dominate the immunopathology of allergic disease.
|
11196697 |
2000 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this review, we describe recent advances in understanding the signal transduction mechanism of IL-13, the involvement of IL-13 signal-related genes as genetic factors in the pathogenesis of bronchial asthma, and the expression of IL-13 receptor on bronchial tissues.
|
11197605 |
2000 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Treatment of RSV-infected mice with anti-IL-13 substantially inhibited airway hyperreactivity.
|
11207314 |
2001 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
To establish this, we initiated this study to examine mRNA expressions of IL-4, IL-10, and IL-13 in duodenal mucosa from patients with asthma.
|
11295668 |
2001 |
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
IL-4 mediates important proinflammatory functions in asthma, including induction of the IgE isotype switch, increased expression of vascular cell adhesion molecule 1 and promotion of eosinophil transmigration across the endothelium, stimulation of mucus production, and T(H)2 lymphocyte differentiation, leading to release of IL-4, IL-5, IL-9, and IL-13.
|
11398072 |
2001 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
In contrast, inhibition of IL-13, another TH2 cytokine whose signal transduction pathway overlaps with that of IL-4, completely blocks airway hyperreactivity in mouse asthma models.
|
11477111 |
2001 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our findings suggest a possible mechanism by which IL-13 and IL-4 can modulate CysLT(1)R expression on monocytes and macrophages, and consequently their responsiveness to LTD(4), and thus contribute to the pathogenesis of asthma and allergic diseases.
|
11509632 |
2001 |
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
As shown by haplotype pattern mining analysis, the number of disease-associated haplotype patterns differed from that expected for the 129Q allele polymorphism in IL13 for high serum total immunoglobulin (Ig) E levels, but not for asthma.
|
11543630 |
2001 |
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population.
|
11588017 |
2001 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Studies in transgenic mice show that both cytokines cause inflammation, but only IL-13 causes subepithelial fibrosis, a characteristic feature of asthma.
|
11588018 |
2001 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The consistent genetic associations of interleukin-13 with asthma and related traits across diverse ethnic populations in these studies provides strong support for the candidacy of this cytokine as a susceptibility locus for asthma and atopy on chromosome 5q31.
|
11667960 |
2000 |
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We tested whether a polymorphism in the coding region of the IL-13 gene is associated with asthma and atopy in asthmatic children in Hong Kong.
|
11678850 |
2001 |
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Asthma is associated with increased production of IL-4 and IL-13.
|
11692112 |
2001 |
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The amounts of IL-13 in supernatant fluids and IFN-gamma mRNA in cells were not statistically different among the BA patients, AD patients and non-allergic controls.
|
11703360 |
2001 |