IL13, interleukin 13, 3596

N. diseases: 587; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.400 AlteredExpression disease BEFREE Two and three doses of MSCs reduced lung inflammation, levels of interleukin (IL)-4, IL-13, and eotaxin; total leukocyte, CD4<sup>+</sup> T-cell, and eosinophil counts in bronchoalveolar lavage fluid; and total leukocyte counts in bone marrow, spleen, and mediastinal lymph nodes. 31746562 2020
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.400 Biomarker disease BEFREE In contrast to oral application, intranasal pretreatment with EcN-Chim prior to poly-sensitization led to a significant reduction of lung inflammation (eosinophils, IL-5, and IL-13 in bronchoalveolar lavage) along with suppressed levels of allergen-specific serum IgE. 30242254 2019
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.400 Biomarker disease BEFREE <b>Objectives:</b> To test the hypothesis that during acute lung inflammation tissue production of proresolution type 2 cytokines (IL-4 and IL-13) dampens the proinflammatory effects of hypoxia through suppression of HIF-1α (hypoxia-inducible factor-1α)-mediated neutrophil adaptation, resulting in resolution of lung injury. 30849228 2019
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.400 Biomarker disease BEFREE Tollip-knockout (KO) and wild-type (WT) mice were inoculated intranasally with recombinant mouse IL-13 protein to examine lung inflammation. 29393212 2018
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.400 AlteredExpression disease BEFREE Alveolar epithelial cells are critical to the pathogenesis of pulmonary inflammation and fibrosis, which are associated with overexpression of type 2 cytokine IL-13. 29672593 2018
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.400 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.400 Biomarker disease BEFREE We now show for the first time that, compared with controls, mice exposed prenatally to secondhand CS exhibit increased lung inflammation (predominant infiltration by eosinophils and polymorphs), atopy, and airway resistance, and produce proinflammatory cytokines (IL-4, IL-5, IL-6, and IL-13, but not IL-2 or IFN-gamma). 19596983 2009
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.400 Biomarker disease BEFREE Exogenous IL-13 reconstituted airway recruitment of leukocytes in OVA-challenged CD3O(-/-) mice.Adoptive transfer to naive w.t. mice of in vitro OVA-re-stimulated spleen cells from CD30(-/-) mice failed to induce eosinophilic pulmonary inflammation in contrast to transfer of primed cells from w.t. mice. 18089617 2008
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.400 Biomarker disease BEFREE IL-13 is involved in pulmonary inflammation, remodeling, and susceptibility to chronic obstructive pulmonary disease (COPD). 17615386 2007
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.400 Biomarker disease BEFREE These findings support a role for IL-13 in maintaining lung inflammation in response to allergen challenge in nonhuman primates. 17379289 2007
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.400 Biomarker disease BEFREE In contrast, neutralization of IL-13 completely abolished both lung inflammation and mucus production. 11781348 2002