|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Irradiated Il17-/- mice lacked Th17 cells, and were spared both fibrosis and pneumonitis, as they survived to the end of the experiment with a significantly increased pulmonary Th1 cell frequency, only.
|
28912510 |
2017 |
|
Pneumonitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Altogether, PTX3 deficiency results in augmented airway hyperresponsiveness, mucus production, and IL-17A-dominant pulmonary inflammation, suggesting a regulatory role of PTX3 in the development of allergic inflammation.
|
27567326 |
2017 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Delayed clearance of the bacteria and stronger lung inflammation observed in infected CS-exposed mice were associated with an altered production of IL-17 and IL-22 by innate immune cells.
|
26870795 |
2015 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Importantly, we demonstrate that PI3K inhibitor significantly suppressed IL-17 production and lung inflammation caused by HP-PRRSV <i>in vivo</i>, implicating that higher IL-17 level induced by HP-PRRSV might be associated with severe lung inflammation.
|
31413135 |
2019 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-17 Plays a Role in Respiratory Syncytial Virus-induced Lung Inflammation and Emphysema in Elastase and LPS-injured Mice.
|
29314865 |
2018 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
This suggests that antioxidant NAC attenuates IL-17A-induced pulmonary inflammation by restoring oxidant-antioxidant balance and attenuation of IL-6 in the lung.
|
30257333 |
2018 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
A cell-permeable decoy peptide based on the CC' loop sequence inhibited IL-17- or IL-25-mediated signaling in vitro, as well as IL-17- and IL-25-induced pulmonary inflammation in mice.
|
22045852 |
2011 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
While the contribution of IL-17/Th17 responses to both physiological and pathological lung inflammation is now well established, the cellular interactions, soluble factors, and signalling pathways that determine Th17 cell responses to fungal infection remain unclear.
|
30816972 |
2019 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we generated an IL-17 KO murine model of hMPV infection and used it to characterize the role of IL-17 hMPV-induced pulmonary inflammation.
|
30077332 |
2018 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we report that MLN4924 can markedly reduce the expression of proinflammatory cytokines and chemokines such as IL-1β, IL-6, and CXCL-1 and neutrophilia in a mouse model of IL-17A adenovirus-induced pulmonary inflammation.
|
30892082 |
2019 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Of note, blockade of IL-17 effectively inhibited the lung inflammation and alleviated ALI severity.
|
26709006 |
2016 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fully reconstituted syngeneic bone marrow transplant (BMT) mice infected with murine γ-herpesvirus-68 develop interleukin-17 (IL-17)-driven pneumonitis and fibrosis, which mimics clinical manifestations of IPS.
|
29044226 |
2018 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression.
|
21625544 |
2011 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In summary, neutrophils may cause tissue damage during lung inflammation through specific functions influenced by IL-17.
|
31634721 |
2019 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Neutrophils and IL17A mediate flagellar hook protein FlgE-induced mouse acute lung inflammation.
|
30412932 |
2019 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Conversely, IL-17-dependent pathology in Zc3h12a(+/-) mice was exacerbated in both EAE and pulmonary inflammation.
|
26320658 |
2015 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Monotherapy of IL-17A mAb partially attenuated lung inflammation in OVA-challenged and ozone-exposed mice, while the combination treatment of Dex and IL-17A mAb effectively reduced lung inflammation, inactivated p38 MAPK and up regulated GR in lung tissue.
|
30917335 |
2019 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Future studies will evaluate the therapeutic efficacy of targeting the IL-17/IL-22 pathway in pulmonary inflammation.
|
24942687 |
2014 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-17A is a critical proinflammatory cytokine for the pathogenesis of asthma including neutrophilic pulmonary inflammation and airway hyperresponsiveness.
|
30683702 |
2019 |
|
Pneumonitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Administration of these two chemical inhibitors similarly inhibited the AHR, the BAL IFN-γ and IL-6 production, the perivascular lung inflammation and the lung IL-17 mRNA expression of OVA-O3 model.
|
29284473 |
2017 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore preventing IL-17 function in CF may prove an important strategy in decreasing lung inflammation due to both direct and indirect effects.
|
19931506 |
2010 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review will go over experimental evidence supporting a role for the IL- 23/IL-17 axis in CF lung inflammation.
|
17607545 |
2007 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-17A and ERS promote lung inflammation in AE-IPF development.
|
30378252 |
2019 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In every aspect of pulmonary inflammation investigated, dexmedetomidine significantly and dose-dependently attenuated the inflammatory effects of IL-17.
|
29030006 |
2018 |
|
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
<b>Objective:</b> To study the effects of an anti-IL17 neutralizing antibody and ROCK inhibitor treatments, separately and in combination, in a murine model of chronic allergy-induced lung inflammation.
|
30233389 |
2018 |