|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We report that allergic lung inflammation is attenuated in absence of either IL-17A or IL-17F with reduced airway hyperreactivity, eosinophilic inflammation, goblet cell hyperplasia, cytokine and chemokine production as found in absence of IL-17RA.
|
29026003 |
2017 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-17A and ERS promote lung inflammation in AE-IPF development.
|
30378252 |
2019 |
|
Pneumonia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Importantly, Act1 deficiency in epithelial cells reduced the phenotype of allergic pulmonary inflammation due to loss of IL-17-induced neutrophilia and IL-25-induced eosinophilia, respectively.
|
19155512 |
2009 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-17A is a critical proinflammatory cytokine for the pathogenesis of asthma including neutrophilic pulmonary inflammation and airway hyperresponsiveness.
|
30683702 |
2019 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore preventing IL-17 function in CF may prove an important strategy in decreasing lung inflammation due to both direct and indirect effects.
|
19931506 |
2010 |
|
Pneumonia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Altogether, PTX3 deficiency results in augmented airway hyperresponsiveness, mucus production, and IL-17A-dominant pulmonary inflammation, suggesting a regulatory role of PTX3 in the development of allergic inflammation.
|
27567326 |
2017 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Reducing pulmonary inflammation by targeting IL-17A may be a therapeutic option in acute P. aeruginosa pneumonia.
|
27634821 |
2016 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we generated an IL-17 KO murine model of hMPV infection and used it to characterize the role of IL-17 hMPV-induced pulmonary inflammation.
|
30077332 |
2018 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review will go over experimental evidence supporting a role for the IL- 23/IL-17 axis in CF lung inflammation.
|
17607545 |
2007 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In summary, neutrophils may cause tissue damage during lung inflammation through specific functions influenced by IL-17.
|
31634721 |
2019 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Conversely, IL-17-dependent pathology in Zc3h12a(+/-) mice was exacerbated in both EAE and pulmonary inflammation.
|
26320658 |
2015 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A cell-permeable decoy peptide based on the CC' loop sequence inhibited IL-17- or IL-25-mediated signaling in vitro, as well as IL-17- and IL-25-induced pulmonary inflammation in mice.
|
22045852 |
2011 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Delayed clearance of the bacteria and stronger lung inflammation observed in infected CS-exposed mice were associated with an altered production of IL-17 and IL-22 by innate immune cells.
|
26870795 |
2015 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
ILC2<sub>17</sub>s are a highly pathogenic and unexpected source for IL-17 in lung inflammation.
|
29625134 |
2019 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Neutrophils and IL17A mediate flagellar hook protein FlgE-induced mouse acute lung inflammation.
|
30412932 |
2019 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
While the contribution of IL-17/Th17 responses to both physiological and pathological lung inflammation is now well established, the cellular interactions, soluble factors, and signalling pathways that determine Th17 cell responses to fungal infection remain unclear.
|
30816972 |
2019 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This suggests that antioxidant NAC attenuates IL-17A-induced pulmonary inflammation by restoring oxidant-antioxidant balance and attenuation of IL-6 in the lung.
|
30257333 |
2018 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Importantly, we demonstrate that PI3K inhibitor significantly suppressed IL-17 production and lung inflammation caused by HP-PRRSV <i>in vivo</i>, implicating that higher IL-17 level induced by HP-PRRSV might be associated with severe lung inflammation.
|
31413135 |
2019 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-17 Plays a Role in Respiratory Syncytial Virus-induced Lung Inflammation and Emphysema in Elastase and LPS-injured Mice.
|
29314865 |
2018 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the role of IL-17 in a CA-MRSA pneumonia animal model.
|
30026066 |
2019 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although defective differentiation of IL-17-producing CD4(+) T cells (Th17) partly accounts for the susceptibility to staphylococcal skin abscesses and pneumonia, the pathogenesis of atopic manifestations in HIES still remains an enigma.
|
21300911 |
2011 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present review is an insight into the involvement and contributions of the proinflammatory cytokine IL-17A in chronic respiratory diseases like Idiopathic Pulmonary Fibrosis (IPF), Chronic Obstructive Pulmonary Distress (COPD), asthma, pneumonia, obliterative bronchiolitis, lung cancer and many others.
|
30652654 |
2019 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Monotherapy of IL-17A mAb partially attenuated lung inflammation in OVA-challenged and ozone-exposed mice, while the combination treatment of Dex and IL-17A mAb effectively reduced lung inflammation, inactivated p38 MAPK and up regulated GR in lung tissue.
|
30917335 |
2019 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In contrast, IL-17A knockout (KO) mice exhibited eosinophil-predominant lung inflammation, decreased AHR, mucus overproduction and increased Th2 cytokine levels and Th2 cells.
|
27589490 |
2017 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Of note, blockade of IL-17 effectively inhibited the lung inflammation and alleviated ALI severity.
|
26709006 |
2016 |