|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
TLR9 in DCs mediated IL-17A production in γδT cells during sepsis and contributed to the development of septic AKI.
|
31760767 |
2020 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, we demonstrated that targeting IL-17A partially rescued the motility of the small intestine and alleviated interstitial cells of Cajal (ICC) injury during sepsis.
|
31531179 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
EEN could regulate the imbalance of Th17/Treg cell ratios and suppress the IL-23/IL-17 axis during sepsis.
|
31236002 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In addition, through the functional (GO) enrichment analysis, we found the genes associated with IL-17A in pediatric sepsis are mainly enriched in the functions of immune response and cell membrane formation.
|
30216518 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Elevated levels of IL-17 and IL-27 are found in the serum of pediatric and adult septic patients early after sepsis onset and have been proposed as diagnostic biomarkers.
|
31507598 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In both non-adjusted and adjusted analyses, IL-17 was the only biomarker significantly associated with sepsis [median serum IL-17 of 72 pg/mL in sepsis versus 37 pg/mL in those without sepsis, P = 0.0001; adjusted odds ratio (OR) 3.2, P = 0.02].
|
28916848 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
We recruited SIRS (n = 33) and sepsis (n = 89) patients from electronic medical records (EMR) according to whether data on PCT, CRP, interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17, IL-22, TNF-α, and IFN-γ levels were available.
|
30547887 |
2018 |
|
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In Alzheimer's disease, the synaptic proteins synaptophysin and PSD-95 were quantified by ELISA, and the inflammatory proteins and mRNAs by MesoScale Discovery Multiplex Assays and qPCR, respectively.Systemic infection in Alzheimer's disease was associated with decreased CD16 (p = 0.027, grey matter) and CD68 (p = 0.015, white matter); increased CD64 (p = 0.017, white matter) as well as increased protein expression of IL6 (p = 0.047) and decreased IL5 (p = 0.007), IL7 (p = 0.002), IL12/IL23p40 (p = 0.001), IL15 (p = 0.008), IL16 (p < 0.001) and IL17A (p < 0.001).
|
30193587 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, when IL-17A pathways are triggered during fetal development, due to chorioamnionitis or in utero inflammatory conditions, IL-17A can instigate and/or exacerbate fetal inflammatory responses that increase neonatal morbidities and mortality associated with common neonatal conditions such as sepsis, bronchopulmonary dysplasia (BPD), patent ductus arteriosus (PDA), and necrotizing enterocolitis (NEC).
|
29243317 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
These findings suggest that IL-17A producing Th17 cells play an essential role in FnBPA<sub>110-263</sub> vaccine-mediated defense against S. aureus sepsis and skin infection in mice.
|
29906512 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Elevated proinflammatory cytokines in sepsis were related to IL-17 from γδT cells.
|
28793286 |
2017 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Filgrastim upregulates expression of these markers, and we observed deficiency in the IL-23-IL-17 axis accompanying sepsis.
|
28769538 |
2017 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Transfer of a normal microbiota into antibiotic-treated neonates induced IL-17 production by group 3 innate lymphoid cells (ILCs) in the intestine, increasing plasma G-CSF levels and neutrophil numbers in a Toll-like receptor 4 (TLR4)- and myeloid differentiation factor 88 (MyD88)-dependent manner and restored IL-17-dependent resistance to sepsis.
|
24747744 |
2014 |
|
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We sought to determine whether there was an association between IL-6, IL-10 and IL-17 polymorphisms with cytokine production and development of sepsis.
|
22079540 |
2012 |
|
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We investigated the hypothesis that the onset of sepsis is related to differential TGFbeta-1 and IL-17 gene expression.
|
20207161 |
2010 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
RGD |
CpG oligodeoxynucleotide protection in polymicrobial sepsis is dependent on interleukin-17.
|
15776385 |
2005 |