|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition, the AS group displayed the highest protein levels of TXNIP, NLRP3, ASC, caspase-1, IL-1β, and IL-18, while the levels of these proteins in the AS + H <sub>2</sub> S group were higher than those in the sham group.
|
30246263 |
2019 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Activation of macrophage inflammasomes leads to interleukin (IL)-1β and IL-18 secretion and promotes atherosclerosis and its complications in mice and humans.
|
30782961 |
2019 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the use of loss- or gain-of-function genetically modified, atherosclerosis-prone mice has provided strong experimental evidence for a causal role of innate and adaptive immunity in atherosclerosis and has revealed the pathogenic activity of proinflammatory cytokines, including TNF (tumor necrosis factor)-α, IL (interleukin)-1β, IL-6, and IL-18, and the atheroprotective effect of anti-inflammatory cytokines, including IL-10 and TGF-β.
|
31294625 |
2019 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The level of IL-17 and IL-18 in the atherosclerosis and disease control groups was higher than that in the healthy control group, and the level of IL-17 and IL-18 in the atherosclerosis was higher than that in the disease control group.
|
30680020 |
2019 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Analysis of interleukin-17 and interleukin-18 levels in animal models of atherosclerosis.
|
31281442 |
2019 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Therefore, in order to investigate IL-18 contribution to the immuno-inflammatory processes underlying atherosclerosis, a systems approach has been used in our studies.
|
30400655 |
2018 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
It is now also known that cholesterol crystals are present through all stages of atherosclerosis and can activate the NLRP3 inflammasome within these inflammatory cells to produce interleukin 1β and interleukin 18 - key mediators in the inflammatory cascade that drive plaque progression and instability.
|
29352570 |
2018 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Several studies have indicated a decisive and important role of NLRP3 inflammasome, IL-1β, IL-18, and pyroptosis in atherosclerosis.
|
28345767 |
2018 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Pyroptosis is characterized by rapid plasma membrane rupture, with the consequent release of intracellular contents and pro-inflammatory mediators, including interleukin (IL)-1β, IL-18, and the alarmin HMGB-1.Recent studies have shown that pyroptosis may be involved in atherosclerosis and play an important role in atherosclerotic lesion instability.
|
29129476 |
2018 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our data demonstrate that TAE protects against IL-18-induced atherosclerosis via NF-κB/PPAR-γ-mediated pathway.
|
28547701 |
2018 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Per os administration of colchicine did not influence atherosclerosis progression in cholesterol-fed rabbits, levels of IL-18, insulin and leptin.
|
28950870 |
2017 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Increased plasma levels of IL-1β and IL-18, aggravated macrophage infiltration into atherosclerotic lesions, and accelerated development of atherosclerosis were detected in HHcy mice as compared with control mice, and were associated with the activation of NLRP3 inflammasomes.
|
28394319 |
2017 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this article, we aimed to present an updated review on these aspects regarding the contribution of IL-18 to important diseases such as cancer, autoimmunity, and inflammatory-mediated conditions including allergic diseases, metabolic syndrome, and atherosclerosis.
|
29478963 |
2017 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The serum levels of IL-1β and IL-18 may be useful predictors of atherosclerosis.
|
26381780 |
2015 |
|
Atherosclerosis
|
0.300 |
Therapeutic
|
disease |
RGD |
Effects of an aqueous extract of Crataegus pinnatifida Bge. var. major N.E.Br. fruit on experimental atherosclerosis in rats.
|
23685195 |
2013 |
|
Atherosclerosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We report that common variation in the interleukin 18 gene is related to acute myocardial infarction, a frequent clinical manifestation of atherosclerosis and thrombosis in coronary arteries.
|
22015107 |
2011 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Increased IL-18 serum levels have been associated with diabetes type 2, metabolic syndrome and the severity of atherosclerosis.
|
22141572 |
2011 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Together with recent reports, showing IL-18 to be predictive for cardiovascular events, our findings could provide the basis for further research of the role of IL-18 as a link and possible target in the association between MetS and atherosclerosis.
|
21842238 |
2011 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, we demonstrated the expression of IL-18BP in atherosclerotic lesions in a rhesus model of atherosclerosis, underscoring the need to fully understand the role of this protein as a primary negative regulator of IL-18 in multiple disease processes.
|
20663688 |
2010 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Moreover, when mice deficient in low-density lipoprotein receptor (LDLR) were bone-marrow transplanted with NLRP3-deficient, ASC (also known as PYCARD)-deficient or IL-1alpha/beta-deficient bone marrow and fed on a high-cholesterol diet, they had markedly decreased early atherosclerosis and inflammasome-dependent IL-18 levels.
|
20428172 |
2010 |
|
Atherosclerosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Among all study subjects, the polymorphism of the IL-18 gene is not associated with subclinical markers of atherosclerosis.
|
20350254 |
2010 |
|
Atherosclerosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
To conclude, IL-18 promoter -137G/C polymorphism influences IL-18 levels and the occurrence of coronary artery disease, suggesting that IL-18 is causally involved in the development of atherosclerosis.
|
18599493 |
2009 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Interleukin-18 is a pro-inflammatory cytokine suspected to be associated with atherosclerosis and its complications.
|
19473509 |
2009 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Collectively, our results demonstrate that the coexpression and regulation of IL-18 and EMMPRIN in the vessel wall may amplify the inflammatory cascade and promote atherosclerosis and remodeling.
|
19561311 |
2009 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
The association between IL-18 and atherosclerosis diminished after accounting for traditional cardiovascular risk factors.
|
17626902 |
2007 |