IL18, interleukin 18, 3606

N. diseases: 750; N. variants: 18
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease BEFREE Serum concentrations of interleukin 18 and 25-hydroxyvitamin D3 correlate with depression severity in men with psoriasis. 30092066 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease BEFREE In T2D, IL-18 and IL-1RA were positively associated with depression for two scores (IL-18: PHQ-9, WHO-5; IL-1RA: CES-D, WHO-5), hsCRP was associated with one depression score (PHQ-9), and adiponectin showed an inverse association with one depression score (PHQ-9) after adjustment (P = 0.006-0.048). 29520075 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 AlteredExpression disease BEFREE Logistic regression analysis showed that higher IL-6 and IL-18 levels at baseline were significantly associated with baseline depression after adjusting for other variables (adjusted p-values=0.005 and 0.001, respectively). 28689006 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 GeneticVariation disease BEFREE These results suggest that a common functional IL18 haplotype associated with heightened proinflammatory responses confers susceptibility to stress-related depression and anxiety through effects on threat-related amygdala function, a risk pathway specific to women. 27430614 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease BEFREE However, the underlying mechanism of this relationship is still not fully explained, while interleukin-6 (IL-6) and interleukin-18 (IL-18) are associated with depression and exercise. 28096677 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease BEFREE Interleukin-18 (IL18) is a multifunctional cytokine that has been implicated in increased susceptibility to depression; however, the underlying mechanism remains unknown. 27590137 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 AlteredExpression disease BEFREE This preliminary report indicates that IL18-607C>A and IL18-137G>C genetic polymorphisms seem to influence depression relapse after antidepressant treatment in our subset of depressed patients, and may possibly contribute to the disregulated IL-18 levels found in patients with depression. 27001087 2016
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease PSYGENET The distribution of six polymorphisms in IL10, IL18 and NF was compared between patients with a single episode of depression either preceded by a stressful life event (n=182), or occurring without a prior stressful life event (n=106) and a group of healthy control individuals (n=335). 21962565 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease BEFREE Our data suggest that this genetic trend towards higher IL-18 production may increase the susceptibility to depression in response to stressful life events. 21962565 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease PSYGENET Interleukin-18 has been found to be over-expressed in human depression and panic disorder as well as other physiological stress paradigms [Takeuchi M, Okura T, Mori T, Akita K, Ohta T, Ikeda M, Ikegami H, Kurimoto M (1999) Intracellular production of interleukin-18 in human epithelial-like cell lines is enhanced by hyperosmotic stress in vitro. 16289586 2006
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease BEFREE Active IL-18 requires cleavage of its precursor form by the IL-1beta-converting enzyme (caspase 1); inhibition of caspase 1 also attenuated the depression in contractile force after I/R (from 35% of control to 75.8% in treated atrial muscle; P < 0.01). 11226333 2001
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease PSYGENET Active IL-18 requires cleavage of its precursor form by the IL-1beta-converting enzyme (caspase 1); inhibition of caspase 1 also attenuated the depression in contractile force after I/R (from 35% of control to 75.8% in treated atrial muscle; P < 0.01). 11226333 2001