IL18, interleukin 18, 3606

N. diseases: 750; N. variants: 18
Disease: Leishmaniasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023281
Disease: Leishmaniasis
Leishmaniasis 		0.310 Biomarker disease BEFREE Moreover, TR4 was able to decrease the levels of IL-10, a cytokine able to render the host macrophage inactive allowing the persistence of parasites inside its phagolysosome, and increase the levels of IL-1β, a cytokine important for host resistance to Leishmania infection by inducible iNOS-mediated production of NO, and IL-18, a cytokine implicated in the development of Th1-type immune response. 29154845 2018
CUI: C0023281
Disease: Leishmaniasis
Leishmaniasis 		0.310 Biomarker disease CTD_human Endogenous interleukin-18 is involved in immunity to Leishmania donovani but its absence does not adversely influence the therapeutic activity of sodium stibogluconate. 16879623 2006