|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Moreover, radiation-induced inflammation, manifested by a noticeable elevation in the level of tumor necrotic factor-alpha (TNF-α), interleukin-18 (IL-18), and C-reactive protein (CRP).
|
31749214 |
2020 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Consistent with our in vitro experiments, analysis of NeuT tumor protein lysates showed that anti-MMP-9 treatment increases expression of CXCL10 and other T cell-stimulating factors, such as interleukin (IL)-12p70 and IL-18.
|
30500835 |
2018 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In conclusion, our data suggest that IL-18 overexpression induces oral SCC cell invasion and metastasis by promoting the tumor cell epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.
|
30524946 |
2018 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Plasma interferon-# and interleukin-18 concentrations in the xenograft tumor model after lipopolysaccharide (LPS) administration were significantly higher than those in the allograft tumor model.
|
29690614 |
2018 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The data obtained show that the high-level production of IL-18 and IL-1β by MAC, overexpression of VEGF-R2 in tumor (at relatively low VEGF-A production), and the high level of IFN-γ production are attributed factors contributing to the formation of a population of low-grade cells in the tumor.
|
29985074 |
2018 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Furthermore, hUMSCs/IL-18 were able to induce a more marked and improved therapeutic effect in the tumor sites, particularly in early tumors.
|
29725393 |
2018 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Finally, the combination of a natural IL-18 inhibitor (IL-18BP) and a PD-1/PD-L1 inhibitor suppressed tumor growth and metastasis in a murine pancreatic cancer model.
|
29599908 |
2018 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Supplementation of IL-18 or transfer of wild-type myeloid cells reduced tumor burden in AOM-DSS-treated Card9<sup>-/-</sup> and Syk<sup>fl/fl</sup>LysM<sup>Cre/+</sup> mice, whereas treatment with anti-fungal agents exacerbated colitis and CRC.
|
30231985 |
2018 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In addition, we demonstrate that IL-18-secreting CAR T cells are capable of modulating the tumor microenvironment, as well as enhancing an effective endogenous anti-tumor immune response.
|
29768210 |
2018 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This study investigates stromal and tumor expression of nuclear factor-kappa B (NF-κB) and interleukin-18 (IL-18) in samples obtained from IBC and noninflammatory locally advanced breast cancer (LABC) and the influence of these markers on patients' prognosis.
|
28766916 |
2018 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Our study revealed a possible correlation between MDSC subsets and IL-18 inducing MDSC migration into the tumor tissue, in addition to provide the potential target to enhance the efficacy of immunotherapy in patients with osteosarcoma.
|
29226090 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Interestingly, the analysis of tumor-infiltrating CD8<sup>+</sup> T cell populations showed that (i) the relative IL-18 receptor (IL-18R) is significantly more expressed by the minority of cells with a functional phenotype (T-bet<sup>+</sup>Eomes<sup>+</sup>), than by the majority of those with the dysfunctional phenotype T-bet<sup>-</sup>Eomes<sup>+</sup> generally resident within tumors; (ii) as a consequence, the former are significantly more responsive than the latter to IL-18 stimulus in terms of IFNγ production <i>ex vivo</i>; (iii) PD-1 expression does not discriminate these two populations.
|
28811967 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Cytokine-induced memory-like natural killer (NK) cells differentiate after short-term preactivation with IL-12, IL-15, and IL-18 and display enhanced effector function in response to cytokines or tumor targets for weeks after the initial preactivation.
|
27894857 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, we investigated the role of tumor-derived IL-18 on peripheral blood NK cells in breast cancer patients.
|
28415798 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Here, we aimed to direct the tumor microenvironment in favor of a successful immune response by local secretion of interleukin (IL-) 12 and IL-18 by sadministered T cells.
|
29296541 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
IL-18 CAR T cell treatment was accompanied by an overall change in the immune cell landscape associated with the tumor.
|
29241547 |
2017 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
As expected, IL1B expression was up-regulated in tumour biopsies especially in metastatic samples, whereas IL18 was down-regulated compared to nevus.
|
27810076 |
2016 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
This includes decreased tumor cell secretion of the immunosuppressive and procancerous cytokines IL-10 and IL-18 and concomitant increased secretion of the proinflammatory cytokines TNF-α, GM-CSF, IL-6 and IL-1β.
|
27242376 |
2016 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Finally, differences in the expression of IL18 in tumor tissue versus nontumor tissue were more predictive of patient outcome than overall tissue expression.
|
26893476 |
2016 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Treatment of BMSCs co-expressing IL-18 and IFN-β significantly prolonged the survival and inhibited tumor growth in a rat intracranial glioma model.
|
26252165 |
2015 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Similar to data previously reported for related inflammasome forming NLRs, the increased inflammation and tumor burden was correlated with attenuated levels of IL-1β and IL-18.
|
25725098 |
2015 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Growing evidence suggests that interleukin-18 (IL-18) levels may affect neoplasia and that single nucleotide polymorphisms (SNPs) within IL-18 gene may influence its production.
|
26600055 |
2015 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Interleukin-18 (IL-18) has been implicated in a wide variety of cellular functions that affect the biological response to tumors.
|
23546966 |
2013 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
However, patients with G/C alleles of IL-18 -137 were correlated with a lower clinical stage (AOR=0.59; 95% CI=0.39-0.89; p=0.01), smaller tumor size (AOR=0.56; 95% CI=0.35-0.87; p=0.01), and non-lymph node metastasis (AOR=0.51; 95% CI=0.32-0.80; p=0.003).
|
24349532 |
2013 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The expression levels of CRY61, CTGF and IL-18 in tumor tissue and VEGF in adjacent noncancerous tissue were modestly associated with prognosis in the training cohort ;Z-score; > 1.5 and were subsequently used to construct a Cox regression-based inflammatory risk score (IRS).
|
23175214 |
2013 |