IL18, interleukin 18, 3606

N. diseases: 750; N. variants: 18
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.300 AlteredExpression disease BEFREE We demonstrated that obesity (P < 0.01), obesity-associated T2D (P < 0.01) and NAFLD (P < 0.05) increased the expression of different components of the inflammasome as well as the expression and release of IL-1β and IL-18 in AT. 31551515 2019
CUI: C0028754
Disease: Obesity
Obesity
0.300 AlteredExpression disease BEFREE We further revealed that activated nod-like receptor protein 3 (NLRP3) inflammasome and its downstream products, i.e., IL-1 family members such as IL-1β and IL-18 were upregulated in the PVAT of obese mini pigs; PVAT dysfunction was also demonstrated in preadipocytes treated with palmitic acid. 30002491 2019
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker disease BEFREE The pyrogenic property being the first activity described, members of the interleukin-1 superfamily (IL-1α, IL-1β, IL-18, and the newest members: IL-33, IL-36, IL-37, and IL-38) are now known to be involved in several inflammatory diseases such as obesity, atherosclerosis, cancer, viral and parasite infections, and auto-inflammatory syndromes as well as liver diseases. 31507607 2019
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker disease BEFREE Predictive Role of Interleukin-18 in Liver Steatosis in Obese Children. 29854715 2018
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker disease BEFREE IL-18 correlated with parameters of obesity, lipids, fasting blood sugar (p < .05) and the number of criteria for MS (p < .001). 29168426 2018
CUI: C0028754
Disease: Obesity
Obesity
0.300 GeneticVariation disease BEFREE Interleukin-18 (IL-18) improves the insulin resistance associated with obesity, but the relationship between IL-18 and glucose metabolism in sepsis was unclear. 27648697 2017
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker disease BEFREE IL-18 mediates diet-induced cardiac dysfunction, independent of food intake and obesity, thus highlighting a disconnect between the metabolic and cardiac effects of IL-18. 28394363 2017
CUI: C0028754
Disease: Obesity
Obesity
0.300 AlteredExpression disease BEFREE IL-18 levels were also high in obese individuals (obese 491±39, lean 301±26 pg/ml; P = 0.0009). 23675517 2013
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker disease BEFREE Interleukin 18 (IL-18) is elevated in lean patients, with a further rise in the presence of obesity and insulin resistance. 22553983 2012
CUI: C0028754
Disease: Obesity
Obesity
0.300 GeneticVariation disease BEFREE Carriage of the A allele at position -607 in the promoter of the IL-18 gene may have a role in the development of obesity. 22531046 2012
CUI: C0028754
Disease: Obesity
Obesity
0.300 GeneticVariation disease BEFREE We investigated variation within the IL18 gene and its association with measures of obesity and the metabolic syndrome. 20227263 2011
CUI: C0028754
Disease: Obesity
Obesity
0.300 Therapeutic disease RGD Furthermore, candesartan increased growth-regulated oncogene, transforming growth factor-beta1 and IL-18 in OZ kidneys to a level higher than LZ or untreated OZ. 20490358 2010
CUI: C0028754
Disease: Obesity
Obesity
0.300 AlteredExpression disease BEFREE CD14 and IL-18 were overexpressed in omental adipose tissue compared with the subcutaneous depot, irrespective of the subject's obesity or diabetes status. 18448614 2008
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker disease BEFREE By their capacity to express inflammatory-related factors, and in particular the proinflammatory cytokine IL-18 in OAT, mesothelial cells appear as a new player in the process of low-grade inflammation associated with obesity. 17637700 2008
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker disease BEFREE AT expression of IL-18 is increased in obesity but not affected by weight loss, indicating that changes in plasma IL-18 are related to insulin resistance rather than changes in obesity per se. 17893261 2007
CUI: C0028754
Disease: Obesity
Obesity
0.300 AlteredExpression disease BEFREE Therefore, variation within IL18, previously shown to be associated with lower IL18 levels, is influencing measures of obesity both in men with type 2 diabetes mellitus and those with advanced coronary heart disease. 17445542 2007
CUI: C0028754
Disease: Obesity
Obesity
0.300 AlteredExpression disease BEFREE The hypothesis that obesity is associated with increased adipose tissue (AT) interleukin (IL)-18 mRNA expression and that AT IL-18 mRNA expression is related to insulin resistance was tested. 17299108 2007
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker disease BEFREE The evolutive advantages of increased inflammatory responses, hypersecretion of proinflammatory cytokines [tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6, and IL-18], or decreased anti-inflammatory molecules (adiponectin, certain TNF-alpha isoforms, soluble CD14, etc.), would lead in westernized countries to chronic inflammation conditions, such as obesity and type 2 diabetes, resulting in cardiovascular disease. 16472051 2006
CUI: C0028754
Disease: Obesity
Obesity
0.300 Biomarker disease BEFREE This finding supports the concepts that adipocytes behave as primitive immune cells and that IL-18 may mediate some of the detrimental complications of obesity such as cardiovascular disease and type 2 diabetes. 15941925 2005