Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that obesity (P < 0.01), obesity-associated T2D (P < 0.01) and NAFLD (P < 0.05) increased the expression of different components of the inflammasome as well as the expression and release of IL-1β and IL-18 in AT.
|
31551515 |
2019 |
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We further revealed that activated nod-like receptor protein 3 (NLRP3) inflammasome and its downstream products, i.e., IL-1 family members such as IL-1β and IL-18 were upregulated in the PVAT of obese mini pigs; PVAT dysfunction was also demonstrated in preadipocytes treated with palmitic acid.
|
30002491 |
2019 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The pyrogenic property being the first activity described, members of the interleukin-1 superfamily (IL-1α, IL-1β, IL-18, and the newest members: IL-33, IL-36, IL-37, and IL-38) are now known to be involved in several inflammatory diseases such as obesity, atherosclerosis, cancer, viral and parasite infections, and auto-inflammatory syndromes as well as liver diseases.
|
31507607 |
2019 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Predictive Role of Interleukin-18 in Liver Steatosis in Obese Children.
|
29854715 |
2018 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-18 correlated with parameters of obesity, lipids, fasting blood sugar (p < .05) and the number of criteria for MS (p < .001).
|
29168426 |
2018 |
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-18 (IL-18) improves the insulin resistance associated with obesity, but the relationship between IL-18 and glucose metabolism in sepsis was unclear.
|
27648697 |
2017 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-18 mediates diet-induced cardiac dysfunction, independent of food intake and obesity, thus highlighting a disconnect between the metabolic and cardiac effects of IL-18.
|
28394363 |
2017 |
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
IL-18 levels were also high in obese individuals (obese 491±39, lean 301±26 pg/ml; P = 0.0009).
|
23675517 |
2013 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Interleukin 18 (IL-18) is elevated in lean patients, with a further rise in the presence of obesity and insulin resistance.
|
22553983 |
2012 |
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Carriage of the A allele at position -607 in the promoter of the IL-18 gene may have a role in the development of obesity.
|
22531046 |
2012 |
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We investigated variation within the IL18 gene and its association with measures of obesity and the metabolic syndrome.
|
20227263 |
2011 |
Obesity
|
0.300 |
Therapeutic
|
disease |
RGD |
Furthermore, candesartan increased growth-regulated oncogene, transforming growth factor-beta1 and IL-18 in OZ kidneys to a level higher than LZ or untreated OZ.
|
20490358 |
2010 |
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
CD14 and IL-18 were overexpressed in omental adipose tissue compared with the subcutaneous depot, irrespective of the subject's obesity or diabetes status.
|
18448614 |
2008 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
By their capacity to express inflammatory-related factors, and in particular the proinflammatory cytokine IL-18 in OAT, mesothelial cells appear as a new player in the process of low-grade inflammation associated with obesity.
|
17637700 |
2008 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
AT expression of IL-18 is increased in obesity but not affected by weight loss, indicating that changes in plasma IL-18 are related to insulin resistance rather than changes in obesity per se.
|
17893261 |
2007 |
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Therefore, variation within IL18, previously shown to be associated with lower IL18 levels, is influencing measures of obesity both in men with type 2 diabetes mellitus and those with advanced coronary heart disease.
|
17445542 |
2007 |
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The hypothesis that obesity is associated with increased adipose tissue (AT) interleukin (IL)-18 mRNA expression and that AT IL-18 mRNA expression is related to insulin resistance was tested.
|
17299108 |
2007 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The evolutive advantages of increased inflammatory responses, hypersecretion of proinflammatory cytokines [tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6, and IL-18], or decreased anti-inflammatory molecules (adiponectin, certain TNF-alpha isoforms, soluble CD14, etc.), would lead in westernized countries to chronic inflammation conditions, such as obesity and type 2 diabetes, resulting in cardiovascular disease.
|
16472051 |
2006 |
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
This finding supports the concepts that adipocytes behave as primitive immune cells and that IL-18 may mediate some of the detrimental complications of obesity such as cardiovascular disease and type 2 diabetes.
|
15941925 |
2005 |