Sarcoidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin-18 (IL-18) has been strongly implicated in the pathogenesis of sarcoidosis.
|
27063085 |
2016 |
Sarcoidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
As genetic factors have been implicated in its aetiology, in our study we investigated whether the promotor polymorphisms in three genes coding for inflammatory mediators interleukin-6 (IL-6), interleukin-12 (IL-12), and interleukin-18 (IL-18) could be associated with susceptibility to sarcoidosis.
|
17671745 |
2007 |
Sarcoidosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In situ hybridization revealed different sites of expression in tuberculosis and sarcoidosis lungs, with AEC-II as one major source of IL-18 in the alveolar compartment.
|
16420594 |
2006 |
Sarcoidosis
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
"Interleukin-18-607 promoter polymorphism in sarcoidosis: ignoring ""negative"" results."
|
16556702 |
2006 |
Sarcoidosis
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Interleukin-18 expression by alveolar epithelial cells type II in tuberculosis and sarcoidosis.
|
16420594 |
2006 |
Sarcoidosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Epithelial lining fluid from active sarcoids contained elevated levels of interleukin-18, interferon-gamma, and interleukin-12 compared with recovered patients and also contained significantly higher levels of endotoxin.
|
16100009 |
2005 |
Sarcoidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, -607 C/A and -656 G/T were significantly associated with serum levels of IL-18 in patients with sarcoidosis, but not in controls.
|
16053025 |
2005 |
Sarcoidosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Roles of functional polymorphisms in the interleukin-18 gene promoter in sarcoidosis.
|
16053025 |
2005 |
Sarcoidosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of IL-18 and tumour necrosis factor-alpha (TNFalpha) mRNA in cells of the BAL of 23 patients with sarcoidosis and nine healthy volunteers was determined using semiquantitative RT-PCR.
|
12735669 |
2003 |
Sarcoidosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Association of single nucleotide polymorphisms in the IL-18 gene with sarcoidosis in a Japanese population.
|
12366781 |
2002 |
Sarcoidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In IL-18 gene polymorphisms, the C allele at position -607 might be a genetic risk factor for sarcoidosis in this Japanese population.
|
12366781 |
2002 |
Sarcoidosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IL-18 mRNA expression was observed in freshly isolated sarcoid BAL fluid cells as well as in LPS-stimulated sarcoid BAL fluid cells, but IFN-gamma and IL-12 mRNA expression was observed only in LPS-stimulated BAL fluid cells.
|
11123348 |
2001 |
Sarcoidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results coupled with those of previous investigations demonstrating activity of IL-18 in inducing interferon-gamma production suggest a significant role of IL-18 in the pathogenesis of sarcoidosis.
|
11580222 |
2001 |
Sarcoidosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We investigated the role of IL-18 in IL-2 expression in sarcoidosis.
|
11035116 |
2000 |
Sarcoidosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Similarly, constitutive expression of IL-18 protein was observed within the airway epithelium of control individuals, with more positive cells found within sarcoidosis tissue (p<0.01) and fewer within asthmatic tissue (p<0.01), compared to controls.
|
10543274 |
1999 |