|
Breast Carcinoma
|
0.140 |
AlteredExpression
|
disease |
BEFREE |
FOXK2 transcription factor suppresses ERα-positive breast cancer cell growth through down-regulating the stability of ERα via mechanism involving BRCA1/BARD1.
|
25740706 |
2015 |
|
Breast Carcinoma
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
Breast Carcinoma
|
0.140 |
AlteredExpression
|
disease |
BEFREE |
Recently, researchers discovered that overexpression of FOXK2 inhibits the proliferation and metastasis of breast cancer, non-small cell lung cancer, and colorectal cancer, and is related to the clinical prognosis.
|
29520156 |
2018 |
|
Breast Carcinoma
|
0.140 |
AlteredExpression
|
disease |
BEFREE |
The forkhead transcription factor FOXK2 plays a critical role in suppressing tumorigenesis and mediating cytotoxic drug action in breast cancer.
|
29540677 |
2018 |
|
Breast Carcinoma
|
0.140 |
AlteredExpression
|
disease |
BEFREE |
Significantly, the expression of FOXK2 is progressively lost during breast cancer progression, and low FOXK2 expression is strongly correlated with higher histologic grades, positive lymph nodes, and ERα<sup>-</sup>/PR<sup>-</sup>/HER2<sup>-</sup> status, all indicators of poor prognosis.
|
27773593 |
2016 |
|
NEURODEVELOPMENTAL DISORDER WITH SPASTIC QUADRIPLEGIA AND BRAIN ABNORMALITIES WITH OR WITHOUT SEIZURES
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Malignant neoplasm of breast
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Recently, researchers discovered that overexpression of FOXK2 inhibits the proliferation and metastasis of breast cancer, non-small cell lung cancer, and colorectal cancer, and is related to the clinical prognosis.
|
29520156 |
2018 |
|
Malignant neoplasm of breast
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Significantly, the expression of FOXK2 is progressively lost during breast cancer progression, and low FOXK2 expression is strongly correlated with higher histologic grades, positive lymph nodes, and ERα<sup>-</sup>/PR<sup>-</sup>/HER2<sup>-</sup> status, all indicators of poor prognosis.
|
27773593 |
2016 |
|
Malignant neoplasm of breast
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The forkhead transcription factor FOXK2 plays a critical role in suppressing tumorigenesis and mediating cytotoxic drug action in breast cancer.
|
29540677 |
2018 |
|
Malignant neoplasm of breast
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
FOXK2 transcription factor suppresses ERα-positive breast cancer cell growth through down-regulating the stability of ERα via mechanism involving BRCA1/BARD1.
|
25740706 |
2015 |
|
Colorectal Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
FOXK2 overexpression promoted CRC migration, invasion and metastasis, while FOXK2 downregulation had the opposite effects.
|
31281520 |
2019 |
|
Colorectal Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Here, we detected FOXK2 expression and its clinical significance in colorectal cancer, which has not been fully investigated before.
|
28007600 |
2017 |
|
Colorectal Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Moreover, FOXK1 and FOXK2 protein levels are elevated in human colorectal cancers and correlate with DVL nuclear localization.
|
25805136 |
2015 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here, we detected FOXK2 expression and its clinical significance in colorectal cancer, which has not been fully investigated before.
|
28007600 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR.
|
31281520 |
2019 |
|
Atrial Fibrillation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate the efficacy and safety of NOAC s in atrial fibrillation patients with ILF .
|
30371232 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study demonstrated that Foxk2 played major roles in NSCLC EMT by directly targeting N-cadherin and Snail, we found that Foxk2 regulated NSCLC cell growth by suppressing the expression of cyclin D1 and CDK4, which suggested that Foxk2 might be a multifunctional regulator in NSCLC.
|
28260088 |
2017 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the biological function of FOXK2 in renal cell carcinoma remains unexplored.
|
29368368 |
2018 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The associations among the expression of FOXK2, clinicopathological parameters, and the prognosis of glioma patients were statistically analyzed.
|
29520156 |
2018 |
|
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Deregulation of miR-140-3p/FOXK2 cascade by hyperglycemia thus serves as an important contributor to angiogenic dysfunction in DM.
|
30862410 |
2019 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The data obtained from the Human Protein Atlas revealed that patients with gastric cancer and a high level of FOXK2 expression had a longer OS time.
|
30221666 |
2018 |
|
Conduct Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared to CD/CU- adolescents, those with CD/CU+ presented increased FA and reduced RD and MD (lower diffusivity) in several tracts including: body and splenium of the corpus callosum, right inferior longitudinal fasciculus, ILF; right inferior fronto-occipital fasciculus, IFOF; left superior longitudinal fasciculus, SLF; left cerebral peduncle, bilateral internal capsule, left superior and posterior corona radiata, bilateral thalamic radiation and left external capsule.
|
29273881 |
2018 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Epigenetically Upregulated MicroRNA-602 Is Involved in a Negative Feedback Loop with FOXK2 in Esophageal Squamous Cell Carcinoma.
|
31401147 |
2019 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our results indicate that FOXK2 inhibits the malignant phenotype of ccRCC and acts as a tumor suppressor possibly through the inhibition of EGFR.
|
29368368 |
2018 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The data obtained from the Human Protein Atlas revealed that patients with gastric cancer and a high level of FOXK2 expression had a longer OS time.
|
30221666 |
2018 |