FOXK2, forkhead box K2, 3607

N. diseases: 32; N. variants: 8
Disease: Breast Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.140 AlteredExpression disease BEFREE Recently, researchers discovered that overexpression of FOXK2 inhibits the proliferation and metastasis of breast cancer, non-small cell lung cancer, and colorectal cancer, and is related to the clinical prognosis. 29520156 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.140 AlteredExpression disease BEFREE The forkhead transcription factor FOXK2 plays a critical role in suppressing tumorigenesis and mediating cytotoxic drug action in breast cancer. 29540677 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.140 GeneticVariation disease GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.140 AlteredExpression disease BEFREE Significantly, the expression of FOXK2 is progressively lost during breast cancer progression, and low FOXK2 expression is strongly correlated with higher histologic grades, positive lymph nodes, and ERα<sup>-</sup>/PR<sup>-</sup>/HER2<sup>-</sup> status, all indicators of poor prognosis. 27773593 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.140 AlteredExpression disease BEFREE FOXK2 transcription factor suppresses ERα-positive breast cancer cell growth through down-regulating the stability of ERα via mechanism involving BRCA1/BARD1. 25740706 2015