Hyperglycemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
These findings demonstrate that hyperglycemia induces metastasis, and C-peptide prevents the hyperglycemia-induced metastasis in the lungs of diabetic mice by inhibiting VEGF-induced TGase2 activation and subsequent vascular leakage.-Jeon, H.-Y., Lee, Y.-J., Kim, Y.-S., Kim, S.-Y., Han, E.-T., Park, W. S., Hong, S.-H., Kim, Y.-M., Ha, K.-S. Proinsulin C-peptide prevents hyperglycemia-induced vascular leakage and metastasis of melanoma cells in the lungs of diabetic mice.
|
30020832 |
2019 |
Hyperglycemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that proinsulin expression in peripheral blood mononuclear cells is a process relevant to this condition and could represent a link among hyperglycemia, nerve susceptibility, and diabetic foot lesions.
|
29436863 |
2018 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Avoiding hyperglycemia in patients with EGI may be important for preventing excessive insulin demand indicated by disproportionately increased proinsulin secretion.
|
29885044 |
2018 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Besides hyperglycemia, other factors contribute to the development of diabetic complications as the proinsulin connecting peptide, C-peptide.
|
29351386 |
2018 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Accumulation of misfolded proinsulin beyond a certain threshold begins to interfere with the normal intracellular transport of bystander proinsulin, leading to diminished insulin production and hyperglycemia, as well as exacerbating ER stress.
|
29377149 |
2018 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to conduct an in-depth analysis of pathological changes in retinas from INS <sup>C94Y</sup> pigs exposed to hyperglycaemia for more than 2 years, representing a chronic diabetic condition.
|
28480495 |
2017 |
Hyperglycemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In addition, SMIT1 expression in INS-1E cells and isolated islets was augmented by acute high-glucose exposure and reduced in chronic hyperglycemia conditions.
|
28202581 |
2017 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We report the correction of hyperglycemia of STZ induced diabetic mice using one intravenous systemic administration of a single stranded serotype 8 pseudotyped adeno-associated virus (ssAAV2/8) vector encoding the human proinsulin gene under a constitutive liver specific promoter.
|
26795016 |
2016 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
INS-gene mutations: from genetics and beta cell biology to clinical disease.
|
25542748 |
2015 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this report we present a family with permanent neonatal diabetes, heterozygous for a novel INS gene missense mutation, p.A24V, manifested with marked hyperglycemia and ketoacidosis, unstable glycemic control, requiring insulin therapy, rapid progression of long-term complications and accompanying physical pathological signs and brain lesions.
|
25765664 |
2015 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
They are common causes of MODY (10-60%): persistent incidental childhood hyperglycemia (10-60%) and gestational diabetes mellitus (1-2%).
|
26106223 |
2015 |
Hyperglycemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Proinsulin levels remained within the normal range (suppressed with hypoglycemia) despite simultaneous almost unmeasurable C-peptide levels during hyperglycemia.
|
23337153 |
2014 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We report a rare case of permanent neonatal diabetes (PND) due to insulin (INS) gene mutation in a 51-month-old girl who presented with hyperglycemia in the neonatal period.
|
23350652 |
2013 |
Hyperglycemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Expression of hProinsulin-B10 in the SMG of chemically induced diabetic mice prevented excessive hyperglycemia observed in untreated mice.
|
23554999 |
2013 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY).
|
20226046 |
2010 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We confirmed that the risk allele of rs7903146 is associated with hyperglycaemia and a higher proinsulin/insulin ratio.
|
19183934 |
2009 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.
|
18192540 |
2008 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.
|
18162506 |
2008 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
CTD_mouse |
Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.
|
18056790 |
2008 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In every patient, fasting insulin, proinsulin, C-peptide and 1,5-anhydro-d-glucitol concentrations were assayed as markers of insulin secretion, peripheral resistance to insulin, and acute hyperglycaemia.
|
17207885 |
2007 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
Insulin gene mutations as a cause of permanent neonatal diabetes.
|
17855560 |
2007 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
These findings indicate that elevated proinsulin and proinsulin/insulin ratios are secondary to increased demands on beta-cell secretion induced by hyperglycemia and insulin resistance with no discernible influence of family history of diabetes.
|
11978587 |
2002 |
Hyperglycemia
|
0.700 |
Biomarker
|
disease |
CTD_human |
Reversible impairment of renal function associated with enalapril in a diabetic patient.
|
9861226 |
1998 |
Hyperglycemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We hope to emphasize instead the homogeneity of nephropathy risk in both IDDM and NIDDM and also the idea that a common genetic susceptibility exists for all types of diabetes and is conditional on cumulative exposure to hyperglycemia.
|
9649955 |
1998 |
Hyperglycemia
|
0.700 |
Therapeutic
|
disease |
CTD_human |
Reversible impairment of renal function associated with enalapril in a diabetic patient.
|
9861226 |
1998 |