INS, insulin, 3630

N. diseases: 405; N. variants: 37
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 Biomarker disease BEFREE Conversely, RILP depletion sustained proinsulin and increased insulin secretion. 31624142 2020
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 Biomarker disease BEFREE Further, our data demonstrate that whole-body insulin resistance is associated with underlying defects in proinsulin secretion, which become detectable only in the presence of increased insulin secretion demand. 30131390 2018
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 Biomarker disease BEFREE In this study, metformin combined with exercise training reduced circulating proinsulin, and both groups taking metformin increased insulin clearance. 28473613 2017
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 GeneticVariation disease BEFREE Another monogenic diabetes gene, the preproinsulin gene (INS), is unique in that INS mutations can cause hyperinsulinemia, hyperproinsulinemia, neonatal diabetes mellitus, one type of maturity-onset diabetes of the young (MODY10), and autoantibody-negative T1D. 27035557 2016
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 AlteredExpression disease BEFREE After 4-week continuous exposure, a hypoglycaemic property of Netrin-1 was demonstrated, which is probably attributable to improved β-cell function, shown as increased insulin content and preproinsulin mRNA expression. 27520508 2016
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 AlteredExpression disease BEFREE PE cells co-cultured with islet cells or islet cell-derived conditioned medium (CM) showed increased expression levels of β-cell markers; significantly higher levels of proinsulin- and Newport Green (NG)-positive cells, which revealed the characteristics of insulin producing cells; and increased insulin secretion upon glucose stimulation. 25173880 2015
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 GeneticVariation disease BEFREE In French obese children, INS VNTR did not associate with fasting insulin levels (P = 0.23) and class I allele showed only borderline association with increased insulin secretion index at 30 min (P = 0.03). 18388898 2008
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 AlteredExpression disease LHGDN Leptin, insulin, and glucose serum levels in large-for-gestational-age infants of diabetic and non-diabetic mothers. 18404969 2008
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 Biomarker disease BEFREE The INS-VNTR class III is more frequent in women who develop GDM, and may be associated with decreased ability of the beta cell to meet the increased insulin requirements as reflected by the need for insulin supplementation for adequate glycaemic control. 17011062 2007
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 Biomarker disease LHGDN Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus. 15538935 2004
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 GeneticVariation disease LHGDN Polymorphisms in candidate genes for type 2 diabetes mellitus in a Mexican population with metabolic syndrome findings. 14693412 2004
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 AlteredExpression disease BEFREE Although all family members were obese, and hyperinsulinemia with high proinsulin and C-peptide was found in all except one sibling, only the mother and one child had overt type 2 diabetes mellitus. 15142366 2004
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 Biomarker disease BEFREE These results show that FDR of NIDDM patients have true hyperinsulinemia (which is not a consequence of cross-reactivity with proinsulin) and hyperproinsulinemia and no dysfunction of a qualitative nature in beta-cells. 10347771 1999
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 AlteredExpression disease BEFREE Non-insulin-treated subjects with the DD genotype had increased insulin sensitivity by HOMA % (DD 56.4%, II 29.4%, P = .027) and lower levels of des 31,32 proinsulin (DD 3.3, II 7.6 pmol.L-1, P = .012) compared with II subjects. 8521557 1995
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 Biomarker disease BEFREE These data suggest that both increased insulin resistance and abnormal processing of proinsulin are present in offspring of parents with diabetes. 7556950 1995
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 Biomarker disease CTD_human Diabetes due to secretion of a structurally abnormal insulin (insulin Wakayama). Clinical and functional characteristics of [LeuA3] insulin. 3511099 1986
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 Biomarker disease CTD_human Posttranslational cleavage of proinsulin is blocked by a point mutation in familial hyperproinsulinemia. 4019786 1985
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 Biomarker disease CTD_human Hyperproinsulinemia in a family with a proposed defect in conversion is linked to the insulin gene. 2991050 1985
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism
0.400 Biomarker disease CTD_human Familial hyperproinsulinemia due to a proposed defect in conversion of proinsulin to insulin. 6382002 1984