|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity.
|
31184304 |
2019 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
CTD_human |
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
|
29035695 |
2018 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Next, the role of INS VNTR in obesity and its related traits is questionable, since recent large-scale studies failed to replicate the earlier positive associations.
|
28615046 |
2017 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
At variance, when both h-INS and obesity were considered, 24-h SBP and DBP were higher in h-INS obese subjects than in the other groups.
|
27142411 |
2017 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion.
|
20534142 |
2010 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We reproduced the association of diabetes-associated variants with proinsulin/insulin ratios, and also examined the association of a TCF7L2 haplotype with obesity in the Framingham Heart Study (FHS).
|
19183934 |
2009 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes.
|
16251897 |
2006 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Defective proinsulin processing leads to glucose intolerance, but neither insulin resistance nor diabetes develop despite obesity.
|
16644867 |
2006 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Predisposition to type 1 diabetes and juvenile obesity is influenced by the susceptibility locus IDDM2 that includes the insulin gene (INS).
|
16380501 |
2006 |
|
Obesity
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The promoter SNP INS CA-11156 was the most consistently associated SNP and was associated significantly with all measures of obesity, except the visceral:subcutaneous ratio (P-values 0.009-0.03).
|
15843989 |
2005 |
|
Obesity
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Multipoint variance component linkage analysis was used to identify genetic location(s) influencing IRS-related traits of obesity (BMI and WC), dyslipidemia (LTG and HDLC), and insulin levels (LSPI); the analysis identified a broad chromosomal region spanning approximately 24 cM.
|
16201139 |
2005 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Heritabilities were highest for the obesity-insulin (INS) factor and lowest for blood pressure (BP) and central obesity.
|
16339118 |
2005 |
|
Obesity
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In multiple regression analysis, fasting levels of proinsulin and proinsulin/insulin ratios were positively associated both with the 2-hour glucose level (as a continuous variable) and with obesity, whereas a negative association was found with birth weight.
|
11978587 |
2002 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Proinsulin in girls: relationship to obesity, hyperinsulinemia, and puberty.
|
12364457 |
2002 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
CTD_human |
Paternal transmission of the very common class I INS VNTR alleles predisposes to childhood obesity.
|
11528401 |
2001 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
For our patients, clinical features are most helpful in differentiating NIDDM-Y from IDDM and include ethnic background, age and gender at diagnosis (approximately 80% of First Nation patients from northern Manitoba are adolescent females), presence of obesity and acanthosis nigricans, lack of symptoms or weight loss, and strong family history of NIDDM.
|
9492113 |
1998 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
BEFREE |
Furthermore, the association of higher insulin and proinsulin levels with the likelihood of a patient having or not having CAD disappears after adjustment for BMI, suggesting that insulin and proinsulin are not independent risk markers but are primarily dependent on obesity.
|
8635646 |
1996 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
CTD_human |
Restoration of growth hormone (GH) response to GH-releasing hormone in elderly and obese subjects by acute pharmacological reduction of plasma free fatty acids.
|
8923850 |
1996 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
CTD_human |
Anthropometric variables and metabolism in polycystic ovarian disease.
|
2777199 |
1989 |
|
Obesity
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|