INS, insulin, 3630

N. diseases: 405; N. variants: 37
Disease: Impaired glucose tolerance ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 Biomarker phenotype BEFREE Proinsulin is sensitive to reflect glucose intolerance. 31222973 2020
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 GeneticVariation phenotype BEFREE In 52 obese children selected for elevated proinsulin levels and/or impaired glucose tolerance, we found eight known variants and two novel heterozygous variants (c.1095 + 1G > A and p.S24C) by sequencing the <i>PCSK1</i> gene. 28271036 2017
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 Biomarker phenotype CTD_human Individuals with impaired glucose tolerance have increased proinsulin levels, despite normal glucose or C-peptide levels. 21779873 2011
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 AlteredExpression phenotype BEFREE In animal models for type 2 diabetes the contents of preproinsulin mRNA are lowered, which might suggest that an impaired metabolism of preproinsulin mRNA contributes to the development of glucose intolerance and diabetes. 18621093 2009
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 AlteredExpression phenotype LHGDN Transgenic expression of human INS gene in Ins1/Ins2 double knockout mice leads to insulin underproduction and diabetes in some male mice. 17127405 2007
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 GeneticVariation phenotype BEFREE Defective proinsulin processing leads to glucose intolerance, but neither insulin resistance nor diabetes develop despite obesity. 16644867 2006
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 Biomarker phenotype BEFREE In adults with impaired glucose tolerance (IGT) and obesity (OB), an elevated proinsulin (PI) is predictive of type 2 diabetes mellitus (DM) and precedes the diagnosis by 5-20 yr. 12364457 2002
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 GeneticVariation phenotype BEFREE Oral glucose tolerance tests on subjects with the presenilin 2 Met239Val mutation unaffected by early onset familial Alzheimer's disease (mean age 35 years) and on their first-degree relatives without the mutation demonstrated no evidence of glucose intolerance or increased proinsulin secretion. 10362543 1999
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 Biomarker phenotype BEFREE At 120' both insulin and proinsulin values increased from NGT to IGT, but with development of diabetes a reduction was seen in the responses. 9768375 1998
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 Biomarker phenotype BEFREE We determined GAD and islet cell (ICA512) autoantibodies from 215 NIDDM individuals and from 14 individuals with impaired glucose tolerance (IGT) of 68 families, including 1 family with maturity-onset diabetes of the young (MODY) and 3 families ascertained specifically for a mixture of NIDDM and IDDM. 9250448 1997
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 AlteredExpression phenotype BEFREE Both fasting and post-glucose levels of proinsulin were elevated in patients with diabetes, but not in the relatives with IGT or NGT. 7821172 1994
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 Biomarker phenotype BEFREE The development of a mild form of IDDM may be expected in cases with pre-existing IGT for more than one year. 2022175 1991
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 AlteredExpression phenotype BEFREE Based on the recent demonstration of elevated serum proinsulin levels in cystic fibrosis patients with impaired glucose tolerance, it was hypothesized that proinsulin could be an indicator of altered beta-cell function. 2792577 1989
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 Biomarker phenotype BEFREE Recent epidemiologic studies of the determinants and natural history of IDDM using HLA typing and detecting islet cell antibodies have shown that HLA-identical siblings of probands with IDDM are at extremely high risk of developing IDDM, and that islet cell antibodies and glucose intolerance usually appear long before clinical manifestations. 3902426 1985