|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Growth factor signaling via insulin receptor (IR) and IGF-1 receptor (IGF1R) plays several important roles in the pathogenesis of metabolic syndrome and diabetes.
|
28646158 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
These include 'insulin receptor binding', and 'negative regulation of glucose import' which are associated with diabetes, 'positive regulation of interleukin-6-mediated signaling pathway', 'regulation of T-helper 2 cell differentiation', 'positive regulation of interleukin-13 production' which are associated with the immune system and 'sertoli cell fate commitment' which is important for male fertility.
|
24334605 |
2014 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Heterozygous individuals expressing both wildtype and mutant tyrosine kinase-defective insulin receptor precursors demonstrate varying degrees of insulin resistance and diabetes.
|
1316361 |
1992 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the metabolic pathway resistance, as obesity diabetes.
|
30453495 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, the defects in glucose-induced insulin secretion (Kir6.2KO) and an insulin resistance in muscle and fat (hIR(KM)TG) were not sufficient to lead to overt diabetes.
|
15118262 |
2004 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mice with combined APP overexpression and diabetes showed a decreased insulin receptor activity and an increased GSK3beta activity.
|
19931251 |
2010 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Defective hepatic insulin receptor (IR) signalling is a pathogenic manifestation of metabolic disorders including obesity and diabetes.
|
26387534 |
2015 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Specific genetic defects have been identified for rate monogenic forms of NIDDM: maturity-onset diabetes of the young, or MODY (which is due to glucokinase mutations in about 40% of families), syndromes of extreme insulin resistance (which often involve the insulin receptor), and diabetes-deafness syndromes (with defects in mitochondrial genes).
|
8712800 |
1996 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest that the tyrosine kinase-deficient insulin receptor causes hyperinsulinemia but not diabetes in these homozygous transgenic mice.
|
9388499 |
1997 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The technique of homozygosity mapping has been used to demonstrate that the mutation causing diabetes in this consanguineous family is genetically linked to the insulin receptor gene.
|
2573522 |
1989 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In mice, the deletion of insulin receptor substrate type 2 (Irs2) causes peripheral insulin resistance and reduction in β-cell mass, leading to overt diabetes, with gender differences on adrenergic signaling.
|
30367392 |
2018 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Also, GLUT4, insulin receptor (IRβ), acetyl coenzyme A (ACC), etc. increased in fat pad of maternal offspring of diabetes.
|
28925477 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Future research with new IR modulators might be considered as possible targets to improve the treatment of diabetes and its associated complications.
|
29201918 |
2017 |
|
Diabetes
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
This inhibitor is orally bioavailable, and it increases liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes.
|
28346406 |
2017 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we established an hIRalpha-specific enzyme-linked immunosorbent assay and measured the plasma IRalpha levels in patients with diabetes.
|
17563065 |
2007 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rodents with tissue-specific knockout of the insulin receptor in the β-cell (βIRKO) show reduced first-phase glucose-stimulated insulin secretion (GSIS) and with aging develop glucose intolerance and diabetes, phenotypically similar to the process seen in human T2D.
|
22928576 |
2012 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we report for the first time that expression of the insulin receptor (IR) in human kidney is altered during diabetes.
|
23059533 |
2013 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that leflunomide sensitizes the insulin receptor by inhibiting S6K1 activity <i>in vitro</i>, and that leflunomide could be potentially useful for treating patients with both RA and diabetes.
|
29496905 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these data demonstrate the novel role of placental InsRs in sex-specific neurodevelopment and reveal a potential mechanism for neurodevelopmental disorder risk in pregnancies complicated by maternal metabolic disorders, including diabetes and obesity.
|
28168960 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In muscle from patients with DM1, altered insulin-receptor splicing to the nonmuscle isoform corresponds to the insulin insensitivity and diabetes that are part of the DM phenotype; because of insulin-receptor species differences, this effect is not seen in mouse models of the disease.
|
15114529 |
2004 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to introduce the foreskin as a novel model to examine developmental programming in human neonates, particularly in regard to adipogenesis and insulin receptor signaling, major contributors to age-associated diseases such as obesity and diabetes.
|
28034763 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Myoinositol ameliorates high-fat diet and streptozotocin-induced diabetes in rats through promoting insulin receptor signaling.
|
28192884 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate whether this was associated with a defective insulin receptor kinase, we studied ten of these young (27 +/- 1 years old) non-obese glucose tolerant first degree relatives of patients with Type 2 diabetes and eight matched control subjects with no family history of diabetes.
|
8395436 |
1993 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that cone snails have evolved diverse strategies to activate the vertebrate insulin receptor and provide unique insight into the design of novel drugs for the treatment of diabetes.
|
30747102 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also focus on novel IR ligands and modulators that should now be considered as an important strategy for better and safer treatment of diabetes and cancer and possibly other IR-related diseases.
|
28973479 |
2017 |