INSR, insulin receptor, 3643

N. diseases: 452; N. variants: 109
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance
0.600 CausalMutation phenotype CLINVAR
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance
0.600 Biomarker phenotype CTD_human Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. 10949030 2000
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance
0.600 Biomarker phenotype CTD_human To evaluate whether hyperglycaemia in two lean patients with primary severe insulin resistance due to insulin receptor (IR) mutations and diabetes mellitus could be reduced by supplement of rosiglitazone for 180 days and secondary, to evaluate the effects on plasma NEFA, TG, Apo B, PAI-1 and serum insulin. 11887975 2001
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance
0.600 Biomarker phenotype HPO
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance
0.600 Therapeutic phenotype RGD Mitofusin-2 ameliorates high-fat diet-induced insulin resistance in liver of rats. 23538485 2013
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance
0.600 ModifyingMutation phenotype RGD Insulin receptor is the target gene of miR-497, and elevated miR-497 might induce hepatic insulin resistance in HFD-MetS E3 Rats through inhibiting the expression of insulin receptor and confining the activation of IRS-1/PI3K/Akt/GSK-3β/GS pathway to insulin. 26300412 2015