INSR, insulin receptor, 3643

N. diseases: 452; N. variants: 109
Disease: Malignant neoplasm of colon and/or rectum ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.070 GeneticVariation disease BEFREE We hypothesize that genetic polymorphisms of insulin receptor substrates (IRS-1 and IRS-2), IGF-I, and IGFBP-3 alter colorectal cancer risk because of their roles in the insulin-related signaling pathway. 15247132 2004
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.070 GeneticVariation disease BEFREE Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect. 17914103 2007
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.070 GeneticVariation disease BEFREE Is there an association between variants in candidate insulin pathway genes IGF-I, IGFBP-3, INSR, and IRS2 and risk of colorectal cancer in the Iranian population? 24175768 2013
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.070 GeneticVariation disease BEFREE An exon variant in insulin receptor gene is associated with susceptibility to colorectal cancer in women. 25557790 2015
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.070 Biomarker disease BEFREE Here, we investigated the effects of inactivating the epithelial insulin receptor in the intestinal tract, in an experimental model of inflammation-induced colorectal cancer. 30137286 2018
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.070 AlteredExpression disease BEFREE Epithelial insulin receptor expression-prognostic relevance in colorectal cancer. 30680065 2018
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.070 GeneticVariation disease BEFREE Although these findings need validation, rotating night shift might increase colorectal cancer risk in women with abnormal insulin receptor pathways. 31666286 2020