INSR, insulin receptor, 3643

N. diseases: 452; N. variants: 109
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 GeneticVariation disease BEFREE Oral HP<i>β</i>CD/Ang-(1-7) treatment decreased <i>ACE</i> and <i>AT1R</i>, increased <i>ACE2</i> gene expression in the liver, and restored thiobarbituric acid reactive substances (TBARS), catalase (CAT), superoxide dismutase (SOD), insulin receptor substrate (<i>Irs-1</i>), glucose transporter type 4 (<i>GLUT4</i>), and serine/threonine kinase 2 (<i>AKT-2</i>) gene expression in the liver and gastrocnemius muscle improving hepatic function, cholesterol levels, and hyperglycemia in MetS rats. 31396301 2019
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 Biomarker disease BEFREE Acute induction of insulin receptor knockout in adipocytes changed the substrate preference to fat before induction of a diabetic phenotype including hyperinsulinaemia and hyperglycaemia. 31309261 2019
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 Biomarker disease BEFREE Non-peptidyl small molecule, adenosine, 5'-Se-methyl-5'-seleno-, 2',3'-diacetate, activates insulin receptor and attenuates hyperglycemia in type 2 diabetic Lepr<sup>db/db</sup> mice. 31378829 2019
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 GeneticVariation disease BEFREE We found that multiple cave populations carry a mutation in the insulin receptor that leads to decreased insulin binding in vitro and contributes to hyperglycaemia. 29562229 2018
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 GeneticVariation disease BEFREE We found that mice with deletion of the insulin receptor alone showed not only hyperglycemia but also a 70% decrease in plasma insulin-like growth factor 1 and delayed growth during the first 2 months of life, a 24-fold increase in the soluble leptin receptor and a 19-fold increase in plasma leptin levels. 29300910 2018
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 Biomarker disease BEFREE Previously we demonstrated that NEU1 activates the insulin receptor (IR) and that NEU1-deficient CathA<sup>S190A-Neo</sup> mice (hypomorph of the NEU1 activator protein, cathepsin A/CathA) on a high-fat diet (HFD) develop hyperglycaemia and insulin resistance faster than wild-type animals. 29735266 2018
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 Biomarker disease BEFREE Insulin receptor (IR) insufficiency in β-cells leads to impaired insulin secretion and reduced β-cell hyperplasia in response to hyperglycemia. 29029025 2018
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 Biomarker disease BEFREE Whether leflunomide can control hyperglycemia and sensitize the insulin receptor has not been tested. 29496905 2018
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 AlteredExpression disease BEFREE Syzygium cumini extract was more efficient than B. forficata in reducing hyperglycaemia, redox disturbances and the changes in mRNA expression of insulin receptor. 28267671 2017
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 AlteredExpression disease BEFREE The expression of the insulin receptor (IR) signaling cascade, including IR, IR substrate, phosphatidylinositol 3-kinase, Akt, and glucose transporter 4, was inhibited both in the skeletal muscle and the liver, which might be a main reason for the hyperglycemia and hyperinsulinemia. 28397090 2017
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 Biomarker disease BEFREE Dose-limiting hyperglycemia has been observed for other IGF1R/INSR inhibitors in clinical trials. 28243682 2017
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 Biomarker disease BEFREE Type B insulin resistance (IR) is a rare autoimmune disease characterized by the presence of insulin receptor autoantibodies, resulting in a marked IR inducing hyperglycemia. 28262212 2017
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 Biomarker disease BEFREE Insulin receptor and insulin receptor substrate-1 (IRS-1) messenger RNA, known stimulate to membrane translocation of Gluts, were both decreased by the HG condition but not by the NG condition. 28624040 2017
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 Biomarker disease BEFREE We recently reported that, targeted deletion of insulin receptor (IR) from proximal tubules (PT) resulted in hyperglycemia in non-obese mice. 27322100 2017
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 GeneticVariation disease BEFREE Donohue syndrome ([DS]; leprechaunism) describes a genetic autosomal recessive disorder that results from the presence of homozygous or compound heterozygous mutations in the insulin receptor gene (INSR; 19p13.3-p13.2).Donohue syndrome is associated with a fatal congenital form of dwarfism with features of intrauterine and postnatal growth retardation, exaggerated hyperglycemia with hyperinsulinism and dysmorphic abnormalities.We present a case of DS owing to the rarity of this syndrome (1 case in every million births). 26871809 2016
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 AlteredExpression disease BEFREE Diet-induced obesity (DIO) in mice developed hyperglycemia and insulin resistance, accompanying with a reduction of insulin receptor (INSR) expression. 26179126 2015
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 GeneticVariation disease BEFREE Leptin treatment has shown some success in treating hyperglycemia in patients with insulin receptor gene mutations. 23047930 2013
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 GeneticVariation disease BEFREE Homozygous or compound heterozygous mutations within the insulin binding domain of the human insulin receptor (INSR) are usually associated with severe impairment of insulin binding leading to Donohue syndrome ("Leprechaunism"), which is characterized by excessive hyperglycemia with hyperinsulinism, pre- and postnatal growth retardation, distinct dysmorphism and early death. 18411068 2008
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 Biomarker disease CTD_human Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects. 18056790 2008
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 Biomarker disease BEFREE Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia. 16278247 2006
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 Biomarker disease BEFREE We tested the hypothesis that impaired insulin receptor signaling in myocytes worsens cardiac remodeling and function following injury, even in the absence of hyperglycemia. 16216265 2005
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 GeneticVariation disease BEFREE To evaluate whether hyperglycaemia in two lean patients with primary severe insulin resistance due to insulin receptor (IR) mutations and diabetes mellitus could be reduced by supplement of rosiglitazone for 180 days and secondary, to evaluate the effects on plasma NEFA, TG, Apo B, PAI-1 and serum insulin. 11887975 2001
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 GeneticVariation disease BEFREE Humans with congenital absence of the islets of Langerhans and mice rendered null for the insulin receptor rapidly develop severe hyperglycemia and ketoacidosis and, if untreated, die in the early neonatal period. 11443207 2001
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 GeneticVariation disease BEFREE We conclude that the Met-985 insulin-receptor variant associates with hyperglycemia and represents a risk factor for NIDDM. 8900242 1996
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.500 Biomarker disease BEFREE (b) Differences in modulation of the insulin receptor signaling cascade are found with TNF-alpha and high glucose: Hyperglycemia-induced insulin receptor inhibition blocks both insulin receptor-dependent tyrosine phosphorylation and dephosphorylation of insulin receptor substrate proteins. 8617880 1996