INSR, insulin receptor, 3643

N. diseases: 452; N. variants: 109
Disease: Impaired glucose tolerance ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 Biomarker phenotype BEFREE Congenital beta cell-specific IR knockout (βIRKO) mouse studies have demonstrated the development of age-dependent glucose intolerance. 31541682 2020
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 Biomarker phenotype BEFREE In females, increased serum leptin, resistin, and IL-6 and reduced adiponectin, caused by visceral obesity, may result in downregulated insulin receptor signaling in muscle and further account for glucose intolerance. 30811831 2019
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 AlteredExpression phenotype BEFREE Before treatment, the fasting and postprandial levels of the insulin receptor were significantly lower in patients with impaired glucose tolerance compared with those in patients with normal glucose tolerance and healthy children. 29168473 2018
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 AlteredExpression phenotype BEFREE The major objective of the current work was to reveal the molecular mechanism by which NEU1 desialylation activates the IR and to test if increase of NEU1 activity in insulin target tissues reverses insulin resistance and glucose intolerance. 29735266 2018
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 AlteredExpression phenotype BEFREE Activation of AMP-activated protein kinase (AMPK) and insulin receptor were not significantly altered suggesting that the improvements in glucose intolerance and IR were independent of enhanced insulin-mediated signaling. 27980001 2017
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 Biomarker phenotype BEFREE Furthermore, 6-month-old IR-IRS1dh mice demonstrated enhanced mitochondrial respiration in skeletal muscle, but a tendency of impaired glucose tolerance. 28556799 2017
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 GeneticVariation phenotype BEFREE Nes<sup>Cre</sup>/PPARγ-P467L mice fed either control diet or high-fat diet displayed impaired glucose tolerance yet exhibited increased sensitivity to exogenous insulin and increased insulin receptor signaling in white adipose tissue, liver, and skeletal muscle. 27575030 2016
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 GeneticVariation phenotype BEFREE Consequently, the exon 11-deleted IR isoform that is less sensitive to insulin is predominantly produced, leading to glucose intolerance in DM1. 25476247 2015
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 PosttranslationalModification phenotype BEFREE To determine whether placental IGF1R, IGFBP3, INSR and IGF1 DNA methylation and mRNA levels were dysregulated when exposed to maternal impaired glucose tolerance (IGT) and investigate whether the epigenetic profile is associated with feto-placental developmental markers. 24811788 2014
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 Biomarker phenotype BEFREE Rodents with tissue-specific knockout of the insulin receptor in the β-cell (βIRKO) show reduced first-phase glucose-stimulated insulin secretion (GSIS) and with aging develop glucose intolerance and diabetes, phenotypically similar to the process seen in human T2D. 22928576 2012
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 AlteredExpression phenotype BEFREE These results strongly suggest that fermented tea activates both PI3K/Akt- and AMPK-dependent signaling pathways to induce GLUT4 translocation and increases the expression of insulin receptor to improve glucose intolerance. 23106150 2012
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 GeneticVariation phenotype BEFREE In contrast to common situation for this genetic disorder, the sisters harbored compound heterozygous mutations in the insulin receptor gene associated with mild glucose intolerance. 19135752 2009
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 AlteredExpression phenotype BEFREE Total IR mRNA expression, but not intrafollicular insulin levels, was elevated in PCOS patients, whereas intrafollicular insulin levels were increased in women with impaired glucose tolerance. 15240646 2004
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 Biomarker phenotype BEFREE K(ATP) channel knockout mice crossbred with transgenic mice expressing a dominant-negative form of human insulin receptor have glucose intolerance but not diabetes. 15118262 2004
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 AlteredExpression phenotype BEFREE In Type 2 diabetes the regularity of the oscillations disappears, which may lead to insulin receptor down-regulation and glucose intolerance and explain why pulsatile delivery of the hormone has a greater hypoglycemic effect than continuous delivery.The rhythm is intrinsic to the islet. 10867718 2000
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 Biomarker phenotype CTD_human Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. 10949030 2000
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.400 GeneticVariation phenotype BEFREE In conclusion, no significant associations were found between insulin receptor gene DNA polymorphisms and glucose intolerance. 1676686 1991