INSR, insulin receptor, 3643

N. diseases: 452; N. variants: 109
Disease: Compensatory Hyperinsulinemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1257965
Disease: Compensatory Hyperinsulinemia
Compensatory Hyperinsulinemia 		0.320 AlteredExpression disease BEFREE The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the metabolic pathway resistance, as obesity diabetes. 30453495 2018
CUI: C1257965
Disease: Compensatory Hyperinsulinemia
Compensatory Hyperinsulinemia 		0.320 GeneticVariation disease BEFREE The findings on INSR rs2115386 are supportive of the role of insulin resistance, or the compensatory hyperinsulinemia, in the pathogenesis of DR. 27768789 2016
CUI: C1257965
Disease: Compensatory Hyperinsulinemia
Compensatory Hyperinsulinemia 		0.320 Biomarker disease CTD_human Two novel mutations in the insulin binding subunit of the insulin receptor gene without insulin binding impairment in a patient with Rabson-Mendenhall syndrome. 18411068 2008
CUI: C1257965
Disease: Compensatory Hyperinsulinemia
Compensatory Hyperinsulinemia 		0.320 Biomarker disease CTD_human Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. 10949030 2000