|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Gene array analysis of HCC tumour tissue from xenograft mice given IP ascorbate (4.0 g/kg/3 days) identified changes in the transcript levels of 192 genes/ncRNAs involved in insulin receptor signalling, metabolism and mitochondrial respiration.
|
31754384 |
2019 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Ectopic overexpression of IR-A in two HCC cell lines presenting a strong autocrine IGF-II secretion loop or not stimulated cell migration and invasion.
|
30849481 |
2019 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
DX-2647, a recombinant human antibody, potently neutralizes the action of insulin-like growth factor-II (IGF-II), a ligand for three cell-surface receptors (IGF-IR, insulin receptor A and B isoforms, and the cation-independent mannose-6-phosphate receptor) which is overexpressed in primary human HCC.
|
29933129 |
2018 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
RGD |
The beta secretase BACE1 regulates the expression of insulin receptor in the liver.
|
29610518 |
2018 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here, we investigated the roles of insulin receptor substrate (Irs) 1 and Irs2, both of which are the major molecules to be responsible for transducing insulin/IGF signaling in the liver, in the development of HCC by inducing chemical carcinogenesis using diethylnitrosamine (DEN) in mice.
|
28710407 |
2017 |
|
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to evaluate the possible roles of IGF-2, insulin-like growth factor-2 receptor (IGF-2R), and insulin receptor substrate (IRS)-2 genes polymorphisms in susceptibility and clinicopathological features of HCC in Egyptian population.
|
24656929 |
2014 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
RGD |
This study identifies a mechanism responsible for the generation of mitogenic IR-A and provides a novel interplay between IR and EGFR pathways in HCC.
|
23633480 |
2013 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
This study identifies a mechanism responsible for the generation of mitogenic IR-A and provides a novel interplay between IR and EGFR pathways in HCC.
|
23633480 |
2013 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We report herein that TWEAK induces cellular insulin resistance in both human hepatocellular carcinoma cell lines (Huh7 and HepG2) and primary rat hepatocytes by inhibiting both early insulin receptor (IR) signaling events and the downstream actions of insulin.
|
18174283 |
2008 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The ability of leptin to augment liver IR activation and PTP1B expression was also observed in vitro in human hepatoma cells (HepG2).
|
14976221 |
2004 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We next studied HTC-IR(Delta485-599) cells, which overexpress a mutant IR with a deletion in the alpha-subunit connecting domain that does not undergo autophosphorylation in response to insulin binding.
|
11574415 |
2001 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Similar levels of IR mRNA were observed in normal tissue, cirrhosis, and HCC.
|
10210639 |
1999 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Failure to replace complete medium resulted in growth arrest of HepG2 cells and a six- to sevenfold increase in insulin-receptor mRNA due to the prolongation of insulin-receptor mRNA half-life.
|
1849849 |
1991 |
|
Liver carcinoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We have now constructed a human insulin receptor mutant in which 3 residues in this sequence were altered (Thr-Cys-Pro-Pro-Pro-Tyr-Tyr-His-Phe-Gln-Asp to Thr-Cys-Pro-Arg-Arg-Tyr-Tyr-Asp-Phe-Gln-Asp) and have expressed this mutant in rat hepatoma (HTC) cells.
|
2550426 |
1989 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Only very high concentrations of insulin-like growth factor I and human proinsulin can compete for the insulin receptor binding and suppress HBsAg production, this suggests that insulin may act through its receptor binding to suppress HBsAg expression in human hepatoma Hep3B cells.
|
2475498 |
1989 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Insulin receptor mRNA levels and insulin binding activity were reduced in HepG2 cultured at lower glucose concentrations.
|
2543399 |
1989 |