Hyperglycemia
|
0.400 |
Biomarker
|
disease |
HPO |
|
|
|
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hyperglycemia recurred within 24 hours of graft removal and the histological analysis of the retrieved grafts revealed presence of Pdx1-, Nkx6.1- and C-peptide-positive cells.
|
23671681 |
2013 |
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice.
|
19757377 |
2010 |
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
PDX-1 was decreased in MIN6N8 cells treated with high glucose or high palmitate, whereas ATF3 was increased, indicating that ATF3 plays a role in hyperglycemia or hyperlipidemia-mediated downregulation of PDX-1 expression.
|
21821004 |
2011 |
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
RGD |
At the same time points, high hyperglycemia rats showed a global alteration in gene expression with decreased mRNA for insulin, IAPP, islet-associated transcription factors (pancreatic and duodenal homeobox-1, BETA2/NeuroD, Nkx6.1, and hepatocyte nuclear factor 1 alpha), beta-cell metabolic enzymes (glucose transporter 2, glucokinase, mitochondrial glycerol phosphate dehydrogenase, and pyruvate carboxylase), and ion channels/pumps (Kir6.2, VDCC beta, and sarcoplasmic reticulum Ca(2+)-ATPase 3).
|
12438314 |
2003 |
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Compromised Pdx1 mRNA and protein levels in weaned male mutant β-cells were tightly linked with hyperglycemia, decreased β-cell proliferation, reduced β-cell area, and altered expression of Pdx1-bound genes that are important in β-cell replication, endoplasmic reticulum function, and mitochondrial activity.
|
28705881 |
2017 |
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hepatic immunoreactive insulin, induced by PDX-1, was processed to mature mI-1 and mI-2 and was biologically active; it ameliorated hyperglycemia in streptozotocin-treated diabetic mice.
|
10909415 |
2000 |
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human BMSCs expressing VEGF and PDX1 reversed hyperglycemia in more than half of the diabetic mice and induced overall improved survival and weight maintenance in all mice.
|
22879915 |
2012 |
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Islets of JNK-1-null mice exposed to hyperglycemia in vivo showed an increase in Pdx-1 and insulin 2 mRNA, whereas islets of wild-type mice did not.
|
30215691 |
2018 |
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
On the contrary, despite normal pancreas and endocrine development, the FVFPBF<sup>DHom</sup> reporter male animals developed hyperglycemia at weaning age and displayed a reduction in Pdx1 levels in islets, which coincided with alterations in β-cell number and islet architecture.
|
28580283 |
2017 |
Hyperglycemia
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Our data further indicate that hyperglycemia decreases gene expression and increases DNA methylation of PDX-1 because glycosylated hemoglobin (HbA1c) correlates negatively with mRNA expression (rho = -0.50, P = 0.0004) and positively with DNA methylation (rho = 0.54, P = 0.00024) of PDX-1 in the human islets.
|
22570331 |
2012 |
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Patients with mutation in genes encoding the transcription factors, hepatocyte nuclear factor (HNF)- 1alpha, HNF-4alpha, HNF-1beta and insulin promoter factor 1 (IPF-1) have a common progressive beta-cell failure resulting in increasing hyperglycaemia and treatment requirements.
|
12173691 |
2002 |
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
RGD |
Prevention of hyperglycemia prevented the associated defects in insulin and PDX-1 gene expression and improved insulin secretion.
|
10512364 |
1999 |
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The suppression of STAT3 signaling, together with exogenously expressed Pdx1, Neurog3, and Mafa, significantly increased the number of reprogrammed β cells in vitro and in vivo, enhanced the formation of islet-like clusters in mice, and ameliorated hyperglycemia in diabetic mice.
|
30266298 |
2018 |
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
While acute exposure to high glucose concentrations causes an increase in PDX-1 binding, and consequently in insulin mRNA levels, chronic hyperglycemia (toxic to the beta-cell) leads to a decrease in PDX-1 and insulin levels.
|
12503852 |
2003 |