|
Pancreatic intraepithelial neoplasia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found that KLK10 was significantly overexpressed in tissues of pancreatic intraepithelial neoplasia (PanIN) and PDAC from Pdx1-Cre; LSL-Kras<sup>G12D/+</sup> mice (KC) and Pdx1-Cre; LSL-Kras<sup>G12D/+</sup>; LSL-Trp53<sup>R172H/+</sup> mice (KPC) by immunohistochemical analysis.
|
29621546 |
2018 |
|
Pancreatic intraepithelial neoplasia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TFF1 expression was also observed in PanIN lesions of Pdx-1 Cre; LSL-KRASG12D (KC) mice, a model of pancreatic cancer, and loss of TFF1 in these mice resulted in the expansion of PanIN lesions, an EMT phenotype in PanIN cells, and an accumulation of cancer-associated fibroblasts (CAFs), eventually resulting in the development of invasive adenocarcinoma.
|
29809170 |
2018 |
|
Pancreatic intraepithelial neoplasia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Quantification of PanINs showed delayed initiation and progression of PanIN lesions at all ages in both homozygous and heterozygous Snail<sup>del1</sup>;Pdx-1-Cre;LSL-Kras<sup>G12D/+</sup>-Mice.
|
29367759 |
2018 |
|
Pancreatic intraepithelial neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, by screening a GEO dataset containing 36 microdissected PDAC and matching normal pancreatic tissue samples, four differentially expressed K<sup>+</sup> channels (KCNJ5, KCNJ16, KCNN4 and KCNK1) were identified in PDAC. by immunohistochemical analysis of pancreatic tissue sections from Pdx1-Cre; LSL-Kras<sup>G12D/+</sup> mice (KC), Pdx1-Cre; LSL-Kras<sup>G12D/+</sup>; LSL-Trp53<sup>R172H/+</sup> mice (KPC) and human PDAC tissue microarrays, we found that Ca<sup>2+</sup>-activated K<sup>+</sup> channel KCNN4 was significantly elevated in pancreatic intraepithelial neoplasia (PanIN) and PDAC epithelia compared with untransformed pancreas tissues.
|
29050937 |
2017 |
|
Pancreatic intraepithelial neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identify a critical role for PDX1 in maintaining acinar cell identity, thus resisting the formation of pancreatic intraepithelial neoplasia (PanIN)-derived PDA.
|
28087712 |
2016 |
|
Pancreatic intraepithelial neoplasia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The proteasome inhibitor markedly reduced PanIN formation in Gdeg;Pdx-1-Cre;LSL-Kras(G12D) mice (P = 0.001), whereas it had no effect on PanIN lesions that had already formed.
|
27244456 |
2016 |
|
Pancreatic intraepithelial neoplasia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We explored lncRNAs profilings in PanIN cell line (SH-PAN) isolated from Pdx-1-Cre; LSL-Kras (G12D/+) mice and PDAC cell line (DT-PCa) isolated from Pdx-1-Cre; LSL- Kras (G12D/+) ; LSL- Tp53 (R172H/+) mice by lncRNAs microarray, and detected expression of lncRNAs and genes in PDAC by Real-time PCR, Western blot, ChIP and immunohistochemistry.
|
24469904 |
2015 |
|
Pancreatic intraepithelial neoplasia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we analyzed the morphological characteristics, molecular alterations, and biological behavior of pancreatic wild-type and neoplasia tissues, including analysis of PanIN cell line SH-PAN (isolated from Pdx-1-Cre; LSL-KrasG12D/+ mouse) and PDAC cell line DT-PCa (isolated from Pdx1-Cre; LSL-KrasG12D/+; LSL-Tp53R172H/+ mouse.
|
23887057 |
2013 |
|
Pancreatic intraepithelial neoplasia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the pancreata of Pdx1-Cre; LSL-Kras(G12D) mice, exendin-4 led to acceleration of the disruption of exocrine architecture and chronic pancreatitis with mucinous metaplasia and increased formation of murine PanIN lesions.
|
22266668 |
2012 |
|
Pancreatic intraepithelial neoplasia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we have evaluated stage specific expression patterns of mucins during mouse PC progression in (Kras(G12D);Pdx1-Cre (KC)) murine PC model from pancreatic intraepithelial neoplasia (PanIN) to pancreatic ductal adenocarcinoma (PDAC) by immunohistochemistry and quantitative real-time PCR.
|
23102107 |
2012 |
|
Pancreatic intraepithelial neoplasia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To better understand the roles of p16 in pancreatic tumorigenesis, we created a conditional p16 knockout mouse line (p16flox/flox), in which p16 is specifically disrupted in a tissue-specific manner without affecting p19/ARF expression. p16flox/flox; LSL-KrasG12D; Pdx1-Cre mice developed the full spectrum of pancreatic intraepithelial neoplasia (mPanIN) lesions, pancreatic ductal adenocarcinoma (PDA), and metastases were observed in all the mice.
|
22113502 |
2011 |
|
Pancreatic intraepithelial neoplasia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In contrast to the uniformly penetrant mPanIN phenotype observed following developmental activation of Kras(G12D) in the Pdx1-expressing progenitor cells, the Pdx1-expressing population in the mature pancreas (predominantly islet beta cells) appears to be relatively resistant to the effects of oncogenic Kras.
|
19028870 |
2008 |