Pancreatic Ductal Adenocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PDX1, a key factor in pancreatic embryogenesis, can exhibit antimetastatic activity in pancreatic ductal adenocarcinoma.
|
31440095 |
2019 |
Pancreatic Ductal Adenocarcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We used LSL-Kras<sup>G12D</sup> ; LSL-Trp53<sup>R172H</sup> ; Pdx-1-Cre (KPC) mice, a mouse model of pancreatic ductal adenocarcinoma (PDAC), and cells isolated from them (KPC cells).
|
31074083 |
2019 |
Pancreatic Ductal Adenocarcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To model this risk, islets and/or pancreatic exocrine clusters obtained from a genetically engineered mouse model for pancreatic ductal adenocarcinoma (the LSL-Kras<sup>G12D/+</sup> ;LSL-Trp53<sup>R172H/+</sup> ;Pdx-1-Cre, termed KPC mouse) were transplanted via the portal vein in syngeneic wild type (WT) severely diabetic recipients in the following treatment groups: group A (n = 11) received KPC exocrine clusters in volume equal to 250 islet equivalents (IEQs); group B (n = 12) received 250 WT IEQs mixed with KPC exocrine clusters (1:1 volume ratio); group C (n = 5) received 250 KPC IEQs, and group D (n = 7) received 250 WT IEQs.
|
28510280 |
2017 |
Pancreatic Ductal Adenocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.
|
28087712 |
2016 |
Pancreatic Ductal Adenocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We determined whether calorie restriction would prevent the development and delay progression of pancreatic intraepithelial neoplasms to pancreatic ductal adenocarcinoma (PDA) in LSL-KrasG12D/+; Pdx-1/Cre mice that develop all the precursor lesions that progress to PDA.
|
23828595 |
2013 |
Pancreatic Ductal Adenocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We crossed a Pdx1-Cre;LSL-KrasG12D mouse, which is a model of pancreatic ductal adenocarcinoma (PDA), with a mouse harboring a floxed allele of Icmt.
|
24216479 |
2013 |
Pancreatic Ductal Adenocarcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In LSL-Kras(G12D)/Pdx-1-Cre/Ink4a/Arf(lox/+) mice, calorie restriction versus overweight- or obesity-inducing diet regimens decreased serum IGF-I, tumoral Akt/mTOR signaling, pancreatic desmoplasia, and progression to pancreatic ductal adenocarcinoma (PDAC), and increased pancreatic tumor-free survival.
|
23980075 |
2013 |
Pancreatic Ductal Adenocarcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we have evaluated stage specific expression patterns of mucins during mouse PC progression in (Kras(G12D);Pdx1-Cre (KC)) murine PC model from pancreatic intraepithelial neoplasia (PanIN) to pancreatic ductal adenocarcinoma (PDAC) by immunohistochemistry and quantitative real-time PCR.
|
23102107 |
2012 |
Pancreatic Ductal Adenocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To better understand the roles of p16 in pancreatic tumorigenesis, we created a conditional p16 knockout mouse line (p16flox/flox), in which p16 is specifically disrupted in a tissue-specific manner without affecting p19/ARF expression. p16flox/flox; LSL-KrasG12D; Pdx1-Cre mice developed the full spectrum of pancreatic intraepithelial neoplasia (mPanIN) lesions, pancreatic ductal adenocarcinoma (PDA), and metastases were observed in all the mice.
|
22113502 |
2011 |
Pancreatic Ductal Adenocarcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of PDX-1 also has been detected in various human pancreatic ductal adenocarcinoma (PDA) cell lines.
|
15457366 |
2004 |