|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to elucidate the relationship between diabetes and PDAC, we investigated the glucose metabolism during tumorigenesis in the LSL-Kras<sup>G12D/+</sup>; LSL-Trp53<sup>R172H/+</sup>; and Pdx-1-Cre (KPC) mouse, a genetically engineered model of PDAC.
|
30989379 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> A PDX1-overexpressing PDAC cell line was obtained by lentiviral transduction of PANC-1 cells.
|
31440095 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
High baseline levels of the ISL1, KRT19, PAX6 and PDX1 mRNAs in PDAC cell lines, were risk factors for time-dependent xenograft appearance after subcutaneous injection in CD1-Nude mice.
|
30293872 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These preclinical data suggest that SHIP1 is a powerful novel promoter that can be used to target human PDAC expressing PDX-1 in clinical trials.
|
29309817 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A clinically translatable αvβ6-targeting NIRF agent was developed, based on a previously developed cysteine knottin peptide for PET imaging, R01-MG, and validated in preclinical mouse models.<b>Experimental Design:</b> The applicability of the agent was tested for cell and tissue binding characteristics using cell-based plate assays, subcutaneous, and orthotopic pancreatic models, and a transgenic mouse model of PDAC development (Pdx1-Cre<sup>tg/+</sup>;KRas<sup>LSL G12D/+</sup>;Ink4a/Arf<sup>-/-</sup>).
|
29298796 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
Biomarker
|
disease |
BEFREE |
Homograft tumors (KPC) are transplants of mouse spontaneous PDAC originating from genetically engineered KPC-mice (Kras<sup>G12D/+</sup>/P53<sup>-/-</sup>/Pdx1-Cre) (KPC-GEMM).
|
30371656 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, by screening a GEO dataset containing 36 microdissected PDAC and matching normal pancreatic tissue samples, four differentially expressed K<sup>+</sup> channels (KCNJ5, KCNJ16, KCNN4 and KCNK1) were identified in PDAC. by immunohistochemical analysis of pancreatic tissue sections from Pdx1-Cre; LSL-Kras<sup>G12D/+</sup> mice (KC), Pdx1-Cre; LSL-Kras<sup>G12D/+</sup>; LSL-Trp53<sup>R172H/+</sup> mice (KPC) and human PDAC tissue microarrays, we found that Ca<sup>2+</sup>-activated K<sup>+</sup> channel KCNN4 was significantly elevated in pancreatic intraepithelial neoplasia (PanIN) and PDAC epithelia compared with untransformed pancreas tissues.
|
29050937 |
2017 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using the transgenic Pdx-1-Cre/KrasG12D /p53R172H (KPC) mouse model, we investigated the mechanism of neural invasion in PDAC.
|
28092668 |
2017 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Deletion of Lfng in the Kras(LSL-G12D/+);Pdx1-Cre mouse model caused increased activation of Notch3 throughout PDAC initiation and progression, and Notch1 after the onset of disease, associated with marked upregulation of Notch target gene Hes1.
|
26279302 |
2016 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
LSL-Kras(G12D/+); LSL-Trp53(R172H/+); Pdx-1-Cre (KPC) mice showed that ETS2 expression initially increased in fibroblasts during ADM and remained elevated through progression to PDAC.
|
27659014 |
2016 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Nevertheless, it is unclear if SIRT1 affects the development of neoplastic lesions and whether metabolic gene expression is altered.To assess neoplastic lesion development, mice with a pancreas-specific loss of Sirt1 (Pdx1-Cre;Sirt1-lox) were bred into a KrasG12D mutant background (KC) that predisposes to the development of pancreatic intra-epithelial neoplasia (PanIN) and ductal adenocarcinoma (PDAC).
|
27494892 |
2016 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We explored lncRNAs profilings in PanIN cell line (SH-PAN) isolated from Pdx-1-Cre; LSL-Kras (G12D/+) mice and PDAC cell line (DT-PCa) isolated from Pdx-1-Cre; LSL- Kras (G12D/+) ; LSL- Tp53 (R172H/+) mice by lncRNAs microarray, and detected expression of lncRNAs and genes in PDAC by Real-time PCR, Western blot, ChIP and immunohistochemistry.
|
24469904 |
2015 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ERG1 expression during PDAC progression was studied in Pdx-1-Cre,LSL-Kras(G12D/+),LSL-Trp53(R175H/+) transgenic (KPC) mice.
|
25719829 |
2015 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fascin-deficient KRas(G12D) p53(R172H) Pdx1-Cre mice had longer survival times, delayed onset of PDAC, and a lower PDAC tumor burdens than KPC mice; loss of fascin did not affect invasion of PDAC into bowel or peritoneum in mice.
|
24462734 |
2014 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also show that Pdx1-Cre/LSL-Kras(G12D)/Smad4(lox/lox) mice heterozygous for Agr2 exhibit a delay in mPanIN initiation and progression to PDAC.
|
22945649 |
2013 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In LSL-Kras(G12D)/Pdx-1-Cre/Ink4a/Arf(lox/+) mice, calorie restriction versus overweight- or obesity-inducing diet regimens decreased serum IGF-I, tumoral Akt/mTOR signaling, pancreatic desmoplasia, and progression to pancreatic ductal adenocarcinoma (PDAC), and increased pancreatic tumor-free survival.
|
23980075 |
2013 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we analyzed the morphological characteristics, molecular alterations, and biological behavior of pancreatic wild-type and neoplasia tissues, including analysis of PanIN cell line SH-PAN (isolated from Pdx-1-Cre; LSL-KrasG12D/+ mouse) and PDAC cell line DT-PCa (isolated from Pdx1-Cre; LSL-KrasG12D/+; LSL-Tp53R172H/+ mouse.
|
23887057 |
2013 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we have evaluated stage specific expression patterns of mucins during mouse PC progression in (Kras(G12D);Pdx1-Cre (KC)) murine PC model from pancreatic intraepithelial neoplasia (PanIN) to pancreatic ductal adenocarcinoma (PDAC) by immunohistochemistry and quantitative real-time PCR.
|
23102107 |
2012 |