|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IRF4 rs12203592*T was associated with BRAF V600E (odds ratio [OR] = 0.59, 95% confidence interval [CI] = 0.43-0.79) and V600K (OR = 0.65, 95% CI = 0.41-1.03), but not BRAF other or NRAS+ melanoma.
|
29753029 |
2018 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Further, higher IRF4 protein levels directed by the rs12203592*C allele were associated with increased basal proliferation but decreased cell viability following UVR, an etiological factor in melanoma development.
|
28755520 |
2018 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest for the first time that IRF4 rs12203592 plays a role in the modulation of melanoma outcome and confirms its contribution to the localization of the primary tumour.
|
28103633 |
2017 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We hypothesize that IRF4 rs12203592 could underlie in part the bimodal age distribution reported for melanoma and linked to the divergent pathways.
|
26857527 |
2016 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results show that IRF4 is overexpressed in melanoma, in addition to previously reported contexts including leukemia, myeloma, and lymphoma, and that IRF4 is associated with a unique gene expression pattern in each context.
|
25207815 |
2014 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A second polymorphism, rs12203592, located on the IRF4 gene was associated with protection to develop MM for the dominant model (p-value 0.037).
|
23537197 |
2013 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Along with two known pigmentation loci, MC1R and OCA2, the IRF4 rs12203592 T allele was associated with an increased risk of each type of skin cancer (P value, 6.6 × 10(-4) for melanoma, 7.0 × 10(-7) for SCC, and 0.04 for BCC).
|
21270109 |
2011 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that the relationship between MTAP and melanoma is subtype-specific, and that the association between IRF4 and melanoma is more evident for cases with a younger age at onset.
|
21962134 |
2011 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IRF4 variants have age-specific effects on nevus count and predispose to melanoma.
|
20602913 |
2010 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
With the exception of desmoplastic and spindle cell melanomas, MUM1 appears to be a sensitive and specific immunohistochemical stain for melanocytic lesions and may prove to be a useful addition to the current panel of melanoma markers.
|
12920225 |
2003 |