Lupus Vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although we could not demonstrate susceptibility toward lupus in the presence of IRF5 rs2004640 (G/T) polymorphism, further exploration of the genetic variability of IRF5 may help uncover its pathogenic role in Indian SLE patients.
|
30168487 |
2018 |
Lupus Vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Enhanced ABC formation in SWEF-deficient mice was controlled by the cytokine IL-21 and IRF5, whose variants are strongly associated with lupus.
|
29483597 |
2018 |
Lupus Vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lineage-Specific Functionality of an Interferon Regulatory Factor 5 Lupus Risk Haplotype: Lack of B Cell Intrinsic Effects.
|
29867973 |
2018 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>IRF5</i> genetic risk has been widely replicated in systemic lupus erythematosus (SLE), and loss of <i>Irf5</i> ameliorates disease in murine lupus models, in part, through the lack of pathogenic autoantibody secretion.
|
29367853 |
2017 |
Lupus Vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of interferon regulatory factor 5 (IRF5) markers with an increased risk of lupus and overlapping autoimmunity in a Kuwaiti population.
|
24697591 |
2015 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study may provide an additional evidence for the association between IRF5 and PTPN22 and lupus susceptibility and may exclude it for CD28, IL2RA, and KIF5A.
|
26092158 |
2015 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interferon regulatory factor 5 and autoimmune lupus.
|
23883595 |
2013 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
A redundant epistatic interaction between IRF5 and STAT4 of the type I interferon pathway in susceptibility to lupus and rheumatoid arthritis.
|
24014567 |
2013 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings demonstrate an intrinsic role for IRF5 in the response of monocytes to pristane and their recruitment to the primary site of inflammation that is thought to trigger lupus onset in this experimental model of SLE.
|
22933628 |
2012 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these data indicate that altered production of IFN-I and other cytokines in IRF5(-/-) mice prevents pristane from inducing lupus pathology by broadly affecting T and B lymphocyte activation/differentiation.
|
22422888 |
2012 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, it remains unclear how IRF5 and Blimp-1 (a transcriptional target of IRF5) contribute to lupus susceptibility.
|
22116829 |
2012 |
Lupus Vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Importantly, our data suggest that in patients with lupus, the presence of the HLA lupus risk alleles in rs1270942 and rs3131379 increases the odds of also carrying the lupus risk allele in IRF5 (rs2070197) by 17% and 16%, respectively (P = 0.0028 and P = 0.0047, respectively).
|
21952918 |
2012 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results show that IRF5 is a crucial driver of lupus development in mice, and indicate that IRF5 may be an attractive new target for therapeutic intervention to control disease in SLE patients.
|
21305501 |
2011 |
Lupus Vulgaris
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that the expression levels of interferon regulatory factor 5 (IRF5), a lupus susceptibility factor, depend on gender of mice.
|
20802013 |
2010 |
Lupus Vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A meta-analysis of the genetic association of the 16 SNPs across populations showed that TNFSF4, STAT4, ITGAM, and IRF5 were associated with lupus in a Hispanic Mestizo cohort enriched for European and Amerindian ancestry.
|
20848568 |
2010 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interferon regulatory factors coordinate the expression of type I IFNs, and the IRF5 gene has been identified as a susceptibility gene of systemic lupus and Sjögren's syndrome.
|
19116937 |
2009 |
Lupus Vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.
|
17412832 |
2007 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, recent studies have not found association of IRF5 with the other autoimmune diseases, such as rheumatoid arthritis or psoriasis, suggesting the unique role for IRF5 in the development of lupus.
|
18075793 |
2007 |