IRF5, interferon regulatory factor 5, 3663

N. diseases: 226; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome
0.140 GeneticVariation disease GWASCAT Genome-Wide Association Analysis Reveals Genetic Heterogeneity of Sjögren's Syndrome According to Ancestry. 28076899 2017
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome
0.140 Biomarker disease BEFREE Genome-wide association studies have implied the association of IRF5 with several autoimmune diseases, including systemic lupus erythematosus (SLE), Sjogren's syndrome, inflammatory bowel disease and multiple sclerosis. 28578407 2017
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome
0.140 Biomarker disease BEFREE The SLE risk haplotype of IRF5 was enriched in all anti-Ro-positive subjects except in those with SS (odds ratio [OR] 2.55, P = 8.8 × 10(-4) ). 22674082 2012
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome
0.140 Biomarker disease BEFREE Interferon regulatory factors coordinate the expression of type I IFNs, and the IRF5 gene has been identified as a susceptibility gene of systemic lupus and Sjögren's syndrome. 19116937 2009
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome
0.140 GeneticVariation disease BEFREE Association of an IRF5 gene functional polymorphism with Sjögren's syndrome. 18050197 2007
CUI: C1527336
Disease: Sjogren's Syndrome
Sjogren's Syndrome
0.140 GeneticVariation disease LHGDN Association of an IRF5 gene functional polymorphism with Sjögren's syndrome. 18050197 2007