IRF7, interferon regulatory factor 7, 3665

N. diseases: 121; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021400
Disease: Influenza
Influenza
0.370 GeneticVariation disease BEFREE Defective interferon priming and impaired antiviral responses in a patient with an IRF7 variant and severe influenza. 31172279 2019
CUI: C0021400
Disease: Influenza
Influenza
0.370 GeneticVariation disease BEFREE These diseases encompass herpes simplex encephalitis (HSE) and severe influenza in IRF3- and IRF7/IRF9 deficiency, respectively. 30671054 2018
CUI: C0021400
Disease: Influenza
Influenza
0.370 Biomarker disease BEFREE These findings suggest that chicken IRF7 could modulate a wide range of cellular processes in the host innate immune response thus meticulous control of IRF7 expression is crucial to the host in response to AIV infection. 30356848 2018
CUI: C0021400
Disease: Influenza
Influenza
0.370 Biomarker disease BEFREE Recently however, human IRF7 was shown to be essential for IFN-α/β- and IFN-λ-dependent protective immunity against primary influenza in vivo, as inferred from a patient with life-threatening influenza revealed to be IRF7-deficient by whole exome sequencing. 26761402 2016
CUI: C0021400
Disease: Influenza
Influenza
0.370 Biomarker disease BEFREE These findings suggest that IRF7-dependent amplification of type I and III IFNs is required for protection against primary infection by influenza virus in humans. 25814066 2015
CUI: C0021400
Disease: Influenza
Influenza
0.370 GeneticVariation disease BEFREE We also identified a common variant in IRF7 that is associated in trans with type I IFN induction in response to influenza infection. 24604203 2014
CUI: C0021400
Disease: Influenza
Influenza
0.370 Biomarker disease CTD_human A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2. 23326326 2013
CUI: C0021400
Disease: Influenza
Influenza
0.370 AlteredExpression disease BEFREE These data demonstrate that infection with influenza results in the reduced expression of transcription factor IRF7 in NECs from smokers, and that these effects may be mediated by an epigenetic modification of the IRF7 gene, thus providing a potential mechanism rendering smokers more susceptible to respiratory virus infections. 19880818 2010