IRF7, interferon regulatory factor 7, 3665

N. diseases: 121; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE In short, we confirmed that although IRF3 is missing in chickens, they employ IRF7 to reconstitute corresponding IFN signaling to respond to both DNA and RNA viral infections. 31366714 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 GeneticVariation group BEFREE Furthermore, the hypomethylation effects of IBDV infection to the promoter regions of IL-6 and IRF7 genes were eliminated and relieved by betaine administration. 31162616 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE These findings suggest that zebrafish RPZ5 is a negative regulator of phosphorylated IRF7 and attenuates IFN expression during viral infection, providing insight into the IFN balance mechanism in fish.<b>IMPORTANCE</b> The phosphorylation of IRF7 is helpful for host IFN production to defend against viral infection; thus, it is a potential target for viruses to mitigate the antiviral response. 31413136 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE These findings provide further support for the essential role of IRF7 in amplifying antiviral IFN responses to ensure potent and sustained IFN responses during influenza virus infection in humans. 31172279 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Here we reported a novel role of IFI204 that specifically inhibits the IRF7-mediated type I interferons response during viral infection. 31603949 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Interferon regulatory factor 7 (IRF7), a crucial regulator of type I interferons (IFNs), plays a crucial role in resistance to viral infection. 30927622 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE After stimulation with polyinosinic-polycytidylic acid (poly I:C) (0.25 μg/ml) for 4 h to mimic viral infection, 293FT wild-type (WT) and IRF7-Δ7 cells were treated with 0, 1, or 100 μM nicotine for 24 h, which increased IFN-β expression in both types of cells but elevation was higher in WT cells (p < 0.001). 31154625 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 AlteredExpression group BEFREE In detail, Irf7 displayed by far the highest gene expression during acute viral infection. 29538462 2018
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 AlteredExpression group BEFREE In addition, a high rate of induced cell death was observed due to elevated level of IRF7 upon viral infection. 30356848 2018
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 AlteredExpression group BEFREE Viral infections in NECs induced IRF7 expression, which correlated with IFN and RANTES expression. 27667736 2017
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Inhibition of PP1 activity significantly increases IRF7 phosphorylation and IRF7-mediated IFN-α production in response to Newcastle disease virus (NDV) infection or Toll-like receptor 7 (TLR7) challenge, leading to impaired viral replication. 27469204 2016
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE The interaction between AIP and IRF7 is enhanced upon virus infection, and AIP potently inhibits IRF7-induced type I IFN (IFNα/β) production. 25911105 2015
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 AlteredExpression group BEFREE Here we found that OASL1 inhibited translation of IRF7, the master transcription factor for type I interferon, and thus negatively regulated the robust production of type I interferon during viral infection. 23416614 2013
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Lung cancer cells can be partially protected from viral killing using IRF5+IRF7 overexpression, whereas IFN pathway disruption by transfection of siRNAs to IRF5+IRF7 increases cells' vulnerability to viral infection. 22194884 2011
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 AlteredExpression group BEFREE These data demonstrate that infection with influenza results in the reduced expression of transcription factor IRF7 in NECs from smokers, and that these effects may be mediated by an epigenetic modification of the IRF7 gene, thus providing a potential mechanism rendering smokers more susceptible to respiratory virus infections. 19880818 2010
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 AlteredExpression group BEFREE Our results indicate that infection with amplicons triggered an interferon (IFN)-regulatory factors 3 and 7 (IRF3/7)-dependent antiviral response, rendered the cells resistant to vesicular stomatitis virus infection and induced significant changes in the pattern of cellular gene expression, including the upregulation of Toll-like receptor 3 (TLR3), IRF7 and IFN-stimulated genes (ISGs). 19515829 2009
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 AlteredExpression group BEFREE Along with IRF3 and IRF7, NSP1 was found to induce the degradation of IRF5, a factor that upregulates IFN expression and that is involved in triggering apoptosis during viral infection. 17301153 2007
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Here, we report a novel immune evasion mechanism of KSHV vIRF3 to block cellular IRF7-mediated innate immunity in response to viral infection. 17522209 2007
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 AlteredExpression group BEFREE Unlike wild type IRF-3, IRF-7 overexpression was able to stimulate inteferon gene expression in the absence of virus infection. 10893229 2000