|
IMMUNODEFICIENCY 39
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency.
|
25814066 |
2015 |
|
IMMUNODEFICIENCY 39
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency.
|
9315633 |
1997 |
|
IMMUNODEFICIENCY 39
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
IMMUNODEFICIENCY 39
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Influenza
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Defective interferon priming and impaired antiviral responses in a patient with an IRF7 variant and severe influenza.
|
31172279 |
2019 |
|
Influenza
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
These diseases encompass herpes simplex encephalitis (HSE) and severe influenza in IRF3- and IRF7/IRF9 deficiency, respectively.
|
30671054 |
2018 |
|
Influenza
|
0.370 |
Biomarker
|
disease |
BEFREE |
These findings suggest that chicken IRF7 could modulate a wide range of cellular processes in the host innate immune response thus meticulous control of IRF7 expression is crucial to the host in response to AIV infection.
|
30356848 |
2018 |
|
Influenza
|
0.370 |
Biomarker
|
disease |
BEFREE |
Recently however, human IRF7 was shown to be essential for IFN-α/β- and IFN-λ-dependent protective immunity against primary influenza in vivo, as inferred from a patient with life-threatening influenza revealed to be IRF7-deficient by whole exome sequencing.
|
26761402 |
2016 |
|
Influenza
|
0.370 |
Biomarker
|
disease |
BEFREE |
These findings suggest that IRF7-dependent amplification of type I and III IFNs is required for protection against primary infection by influenza virus in humans.
|
25814066 |
2015 |
|
Influenza
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
We also identified a common variant in IRF7 that is associated in trans with type I IFN induction in response to influenza infection.
|
24604203 |
2014 |
|
Influenza
|
0.370 |
Biomarker
|
disease |
CTD_human |
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
|
23326326 |
2013 |
|
Influenza
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
These data demonstrate that infection with influenza results in the reduced expression of transcription factor IRF7 in NECs from smokers, and that these effects may be mediated by an epigenetic modification of the IRF7 gene, thus providing a potential mechanism rendering smokers more susceptible to respiratory virus infections.
|
19880818 |
2010 |
|
Major Depressive Disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
We found these results to be concordant with our observation of decreased expression of IRF7 in the prefrontal cortex of MDDs with negative toxicological evidence for antidepressant treatment at the time of death.
|
22832429 |
2011 |
|
Major Depressive Disorder
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We found these results to be concordant with our observation of decreased expression of IRF7 in the prefrontal cortex of MDDs with negative toxicological evidence for antidepressant treatment at the time of death.
|
22832429 |
2011 |
|
Unipolar Depression
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Gene expression biomarkers of response to citalopram treatment in major depressive disorder.
|
22832429 |
2011 |
|
Inflammation
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Type I interferon signaling contributes to chronic inflammation in a murine model of silicosis.
|
20513754 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Transancestral mapping and genetic load in systemic lupus erythematosus.
|
28714469 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, inhibition of Pin1 using either validated Pin1 shRNA or ATRA blocked TLR-7-induced activation of IRAK-1 and IRF-7 in SLE patient-derived immune cells.
|
27159270 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.
|
27399966 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
The type-I interferon master regulator gene IRF7 is only hypomethylated in lupus patients with renal involvement.
|
26005050 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
IRF7, a functional factor associates with systemic lupus erythematosus.
|
22455868 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
These results confirmed recently reported association of PHRF1 rs4963128T with anti-Sm antibody positive SLE in African-American populations, and supported the role of PHRF1-IRF7 region in the genetics of SLE.
|
22433914 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
Recent studies have reported an association between IRF7 and SLE which confers a risk to autoantibody production.
|
21926187 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.200 |
Biomarker
|
disease |
BEFREE |
This result provides direct genetic evidence that IRF7 may be a risk gene for human SLE.
|
21360504 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We decided to investigate the association of single-nucleotide polymorphisms (SNPs) in the IRF7/KIAA1542 region (rs4963128, rs2246614, and rs702966) and in STAT4 (rs7574865 and rs7582694) with SLE disease in a Northern Han Chinese population of 748 patients and 750 healthy controls.
|
21167895 |
2011 |