IRS1, insulin receptor substrate 1, 3667

N. diseases: 233; N. variants: 15
Disease: Hyperinsulinism ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.400 Biomarker disease BEFREE Insulin increased insulin receptor substrate 1 (IRS-1) tyrosine phosphorylation, IRS-1-associated phosphatidylinositol (PI) 3-kinase activity, and phosphorylation of Akt Ser473 and AS160, a newly described Akt substrate that plays a role in GLUT4 exocytosis, approximately 2.3 fold before treatment. 15855334 2005
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.400 GeneticVariation disease BEFREE We show that Igf1r/Irs1 double mutants do not differ phenotypically from Irs1 single mutants and exhibit hyperinsulinemia, while maintaining normal β cell mass and glucose tolerance. 20947509 2010
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.400 GeneticVariation disease BEFREE Common genetic variants in the insulin receptor substrate 1 (IRS1) gene have been recently associated with insulin resistance and hyperinsulinemia. 21747052 2011
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.400 Biomarker disease BEFREE In obesity and type 2 diabetes, selective downregulation of Irs2 and its downstream actions to cause reduced insulin actions was associated with increased insulin actions through Irs1 in variety tissues. 28380373 2017
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.400 Biomarker disease BEFREE Additionally, TBF treatment significantly reduced phosphorylation of insulin receptor substrate 1 (IRS-1) at serine 307 and increased insulin-stimulated Akt/eNOS activation in the SHRs. 29043342 2017
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.400 Biomarker disease BEFREE We characterised expression of IR-related molecules, IRS-1 phosphorylation and downstream signalling in a panel of 5 colon cancer cell lines at different insulin exposures: 15 min (100 nM), approximating to acute stimulation; 48 h (100 nM), used to demonstrate adaptive changes; and 12 weeks (20 nM; chronic insulin exposure, CIE), approximating to chronic hyperinsulinaemia. 24068609 2014
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.400 AlteredExpression disease BEFREE We conclude the following: 1) physiological hyperinsulinemia induces sustained activation of insulin-signaling molecules in human skeletal muscle; 2) the more distal insulin-signaling components (Akt, GSK-3) are activated much more rapidly than the proximal signaling molecules (IRTK as well as insulin receptor substrate 1 and phosphatidylinositol 3-kinase [Wojtaszewski et al., Diabetes 46:1775-1781, 1997]); and 3) prior exercise increases insulin stimulation of both glucose uptake and glycogen synthase activity in the absence of an upregulation of signaling events in human skeletal muscle. 10868952 2000
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.400 PosttranslationalModification disease BEFREE In vivo hyperglycemia/hyperinsulinemia in rats for 48 hours similarly resulted in activation of PKC-ζ and increased phosphorylation of IRS-1 Ser318 and Akt Thr34. 29370351 2018
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.400 Biomarker disease BEFREE Allelic variants of genes encoding components of the insulin pathway, including insulin (INS), insulin receptor (INSR), and insulin receptor substrate-1 and insulin receptor substrate-2 (IRS1 and IRS2) have been associated with hyperinsulinemia and insulin resistance and may, therefore, predict susceptibility to colorectal neoplasia. 17416760 2007
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.400 GeneticVariation disease BEFREE Unlike previously reported T2D risk loci, which predominantly associate with impaired beta cell function, the C allele of rs2943641 was associated with insulin resistance and hyperinsulinemia in 14,358 French, Danish and Finnish participants from population-based cohorts; this allele was also associated with reduced basal levels of IRS1 protein and decreased insulin induction of IRS1-associated phosphatidylinositol-3-OH kinase activity in human skeletal muscle biopsies. 19734900 2009
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.400 Biomarker disease CTD_human Unlike previously reported T2D risk loci, which predominantly associate with impaired beta cell function, the C allele of rs2943641 was associated with insulin resistance and hyperinsulinemia in 14,358 French, Danish and Finnish participants from population-based cohorts; this allele was also associated with reduced basal levels of IRS1 protein and decreased insulin induction of IRS1-associated phosphatidylinositol-3-OH kinase activity in human skeletal muscle biopsies. 19734900 2009