|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We investigated associations between TNF-α <sup>-308</sup>G > A (rs1800629); PPARγ Pro<sup>12</sup>Ala (rs1801282); and IRS-1 Gly<sup>972</sup>Arg (rs1801278) polymorphisms and anthropometric variables, circulating levels of previously measured biomarkers, and tumor characteristics in 553 women enrolled in the Health, Eating, Activity, and Lifestyle Study, a multiethnic, prospective cohort study of women diagnosed with stage I-IIIA breast cancer between 1995 and 1999 (median follow-up 14.7 years).
|
29256014 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
LNCaP cells are human prostatic cancer cells that have a frame-shift mutation of the tumor suppressor gene PTEN and do not express the insulin receptor substrate-1 (IRS-1), a major substrate of the type 1 insulin-like growth factor receptor (IGF-IR).
|
11313980 |
2001 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Moreover, we demonstrated that disruption of protein-protein interaction between p110α helical domain mutant and IRS1 inhibits the growth of tumors with such mutations.
|
24178578 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The significance of our findings for human breast cancer is heightened by our observation that Irs-1 is inactivated in wild-type, metastatic mammary tumors by serine phosphorylation.
|
17030605 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These studies suggest that constitutive IRS-1 activation is a common phenomenon in tumors and that activated IRS-1 may present an attractive therapeutic target.
|
12414625 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we demonstrate that LPIN1 enhances the tumour-promoting function of insulin receptor substrate 1 (IRS1) by controlling IRS1 stability.
|
27729374 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
LIN28B/IRS1 axis is targeted by miR-30a-5p and promotes tumor growth in colorectal cancer.
|
31713927 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Allelic variants of genes encoding components of the insulin pathway, including insulin (INS), insulin receptor (INSR), and insulin receptor substrate-1 and insulin receptor substrate-2 (IRS1 and IRS2) have been associated with hyperinsulinemia and insulin resistance and may, therefore, predict susceptibility to colorectal neoplasia.
|
17416760 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results showed that IGF-I, IGF-IR mRNAs, and phospho-insulin receptor substrate-1 (IRS-1) protein were decreased in ECC-1TAM compared with ECC-1E2 tumors.
|
16166331 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Molecular and Structural Traits of Insulin Receptor Substrate 1/LC3 Nuclear Structures and Their Role in Autophagy Control and Tumor Cell Survival.
|
29483302 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Insulin receptor substrate-1 (IRS1) was identified as a target gene of miR-145, by which miR-145 was able to suppress cell proliferation. miR-145 suppresses cell proliferation, anchorage-independent growth, cell motility, and may serve as a tumor suppressor.
|
23714355 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Several single-nucleotide polymorphisms of IGF1R, IGF2R, and IRS1 gene were significantly associated with tumor response to therapy and disease stage.
|
20416304 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Treatment of Kras/Irs-1(+/+) and Kras/Irs-1(-/-) mice with JAK inhibitors significantly reduced tumor burden, most notably in the IRS-1-deficient group.
|
27439864 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The mechanism by which IRS-1 supports tumor growth is not fully understood, and the argument that IRS-1 merely amplifies the signal from the IGF-1R and/or IR requires further investigation.
|
22454254 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The association of post-diagnosis physical activity with colorectal carcinoma patient survival may differ by tumor IRS1 expression level.
|
26577117 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have found that approximately 40% of 22 human hepatocellular carcinoma (HCC) tumors had enhanced (>200%) hIRS-1 gene expression compared with adjacent non-involved liver tissue.
|
9303488 |
1997 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Higher levels of hIRS-1 gene transcripts were observed in HCC tumors compared to adjacent non-involved normal liver.
|
1311924 |
1992 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
BT-20 cells form tumors in xenografts in mice, but the size of tumors is twice as large when the cells express IRS-1.
|
17332342 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Statistical analysis (ROC analysis for tumor grade) demonstrated that down-regulation of IGF-IR and IRS-1 correlated better with tumor progression than reduction of ER expression or increase in cell proliferation, IGF-IR showing the best correlation, followed by IRS-1 and, less significant, ER and Ki67.
|
11102895 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we found a negative correlation of IRS-1 expression with tumor metastasis both in human tissue samples and in cell lines.
|
22664743 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MiR-145 also inhibited N-RAS and IRS1 expression to suppress AKT and ERK1/2 activation, and VEGF expression in mouse xenograft tumors.
|
23201159 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IRS1 indicated over-expression in tumour.
|
21978709 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IRS-1 was expressed at high levels in estrogen-dependent growth of MCF-7 xenografts, but withdrawal of estrogen, which decreased tumor growth, resulted in a dramatic decrease in IRS-1 expression.
|
10319328 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon.
|
25477374 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In breast cancer, IRS-1 overexpression has been associated with tumor development, hormone-independence and antiestrogen-resistance.
|
16440325 |
2006 |