|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We also observed a weak interaction of the IGF1R IVS2+46329T>C and IGF2R Ex45+11C>T (L2222L) genotypes with diabetes (P(interaction)=.05) and interaction of IGF2R and IRS1 genotypes with alcohol consumption (P(interaction)=.03 and .019, respectively) on increased pancreatic cancer risk.
|
21852217 |
2012 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to evaluate the role of the IRS-1 gene G972R variant in 61 subjects with "uncomplicated" obesity [i.e. without diabetes, hypertension, dyslipidemia, coronary artery disease (CAD)], studied by hyperinsulinemic-euglycemic clamp.
|
15636429 |
2004 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Also, the diagnostic test to exclude diabetes amongst control subjects interacted with the association between the IRS-1 Gly972Arg variant and Type 2 diabetes (p=0.03).
|
12819898 |
2003 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The IRS-1 gene variant was associated with a higher frequency of diabetes mellitus (14.9% among carriers versus 6.5% among noncarriers; P<0.01) and with a 60% increase of plasma total triglycerides (P<0.001).
|
10591678 |
1999 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa.
|
24447396 |
2014 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The ENPP1 121Gln and IRS-1 972Arg polymorphisms were detected in 28.7% and 18.1% of patients and associated with increased body weight/dyslipidaemia and diabetes risk, respectively.
|
20176643 |
2010 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The diabetes risk variant rs7578326 located near the IRS1 locus was associated with both macroscopic (OR = 0.73, p = 0.011) and microscopic (OR = 0.71, p = 0.009) infarct pathology.
|
24135527 |
2013 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The GLUT2 and IRS1 amino acid polymorphisms did not show a simple pattern of co-inheritance with NIDDM in the families of these subjects suggesting that neither polymorphism is sufficient to cause NIDDM but may increase diabetes-susceptibility through their interaction with other loci and environmental factors.
|
7713316 |
1995 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The allele frequencies of the Gly972Arg variant of the insulin receptor substrate-1 (IRS-1) gene and the Ala54Thr variant of the fatty acid binding protein 2 (FABP2) gene were compared in 992 normal control subjects and three patient groups: 1) 321 type 2 diabetic individuals, 2) 260 severely obese individuals, and 3) 258 markedly hyperinsulinemic individuals without diabetes.
|
10480621 |
1999 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The GNB3 825T allele and the IRS-1 972Arg variant were significantly associated with diabetes (odds ratios for either variant 1.4 1.8).
|
11121369 |
2000 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Insulin receptor substrate 1 (IRS1) variants confer risk of diabetes in the Boston Puerto Rican Health Study.
|
23353623 |
2013 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The X-Arg genotype of IRS-1 was significantly associated with a positive family history of diabetes in NGT (P = .006) and neared significance in GDM (P = .057).
|
17046546 |
2006 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Subjects with at least 1 copy of the Gly972Arg polymorphism of the IRS1 gene showed a greater risk for diabetes, with a crude odds ratio of 3.26 (95% confidence interval, 2.00-5.33); after adjusting for BMI, age, family history of T2D, and sex, the odds ratio was 2.91 (95% confidence interval, 1.73-4.90).
|
19716569 |
2010 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
We conclude the following: 1) physiological hyperinsulinemia induces sustained activation of insulin-signaling molecules in human skeletal muscle; 2) the more distal insulin-signaling components (Akt, GSK-3) are activated much more rapidly than the proximal signaling molecules (IRTK as well as insulin receptor substrate 1 and phosphatidylinositol 3-kinase [Wojtaszewski et al., Diabetes 46:1775-1781, 1997]); and 3) prior exercise increases insulin stimulation of both glucose uptake and glycogen synthase activity in the absence of an upregulation of signaling events in human skeletal muscle.
|
10868952 |
2000 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
We provide such a demonstration here by showing that the hippocampal formation (HF) and, to a lesser degree, the cerebellar cortex in AD cases without diabetes exhibit markedly reduced responses to insulin signaling in the IR→IRS-1→PI3K signaling pathway with greatly reduced responses to IGF-1 in the IGF-1R→IRS-2→PI3K signaling pathway.
|
22476197 |
2012 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
The IRS-1 exhibited a diurnal rhythm in control mice; however, with diabetes, this natural rhythm was lost.
|
31042800 |
2019 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Insulin receptor substrate-1 and -2 (IRS-1 and IRS-2), two major downstream molecules of IGF-1R, are known to be important in the genesis of diabetes.
|
14604996 |
2004 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Although the mechanisms underlying the regulation of IRS-1 in the nutrient-rich conditions associated with diabetes and insulin resistance have been well studied, those under nutrient-poor conditions remain unknown.
|
29786968 |
2019 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Our study suggests that HD prevents the development of diabetes and improves renal function in the <i>db/db</i> mice and HD regulation of the IRS1-PI3K-GLUT signaling pathway significantly improves diabetic nephropathy.
|
30210687 |
2018 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Given the documented importance of IRS-1 and -2 in insulin signalling and the implications of distribution of these genes for the pathogenesis of insulin resistance and diabetes, we decided that the most recently identified member of the IRS family, IRS-4, was a relevant candidate to examine for genetic variability which might be associated with subsets of diabetes or insulin resistance.
|
9726601 |
1998 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Thus, dual targeting of AMPK and IRS-1 might provide an ideal way to treat diabetes.
|
29259227 |
2017 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Moreover, ER stress CHOP, GRP78 and ATF4 biomarkers level were significantly attenuated in PCr treated animals comparing to STZ diabetes associated liver-damage model with significant improving in insulin-resistance Akt and IRS-1.
|
30366667 |
2018 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
The insulin-signaling pathway requires insulin receptor substrate 1 (IRS1) and IRS2, which are found to be dysregulated in diabetes and obesity.
|
30770439 |
2019 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Because IRS-1 is down-regulated in states of insulin resistance that occur in response to metabolic stresses such as obesity and cytokine stimulation, the findings provide a mechanism for understanding how patients with metabolic stress and/or diabetes are predisposed to developing vascular complications.
|
28003360 |
2017 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Disruption of IRS-1 in mice retards growth, but diabetes does not develop because insulin secretion increases to compensate for the mild resistance to insulin.
|
9495343 |
1998 |