IRS1, insulin receptor substrate 1, 3667

N. diseases: 233; N. variants: 15
Disease: Metabolic Syndrome X ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.300 Biomarker disease BEFREE Mitsugumin 53 (MG53 or TRIM72), a striated muscle-specific E3 ligase, promotes ubiquitin-dependent degradation of the insulin receptor and insulin receptor substrate-1 and subsequently induces insulin resistance, resulting in metabolic syndrome and type 2 diabetes mellitus (T2DM). 30586741 2019
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.300 Biomarker disease BEFREE These findings suggest that C1-Ten inhibition by DHTS could provide a novel therapeutic strategy for insulin resistance-associated metabolic syndrome through dual targeting of IRS-1 and AMPK. 29259227 2017
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.300 AlteredExpression disease BEFREE The underlying mechanism was attenuation of the reduced expression of PI3K p85 mRNA and IRS1 protein in both insulin-resistant HepG2 cells and MS rats. 24555840 2014
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.300 GeneticVariation disease BEFREE Our data suggest that high-fat weight-loss diets might be more effective in the management of the MetS compared with low-fat diets among individuals with the A-allele of the rs1522813 variant near IRS1. 24009303 2013
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.300 AlteredExpression disease BEFREE Differential regulation of IRS1 and IRS2 and of their downstream effectors AKT1 and AKT2 is consistent with upregulation of FOXO1 and may justify the paradoxical state of insulin resistance relative to the glucoregulatory pathway and augmented insulin sensitivity of the liporegulatory pathway typical of steatosis and the metabolic syndrome in obese patients. 23147115 2013
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.300 GeneticVariation disease BEFREE Subsequent analyses showed that MC4R rs17782312, involved in weight regulation, and IRS1 rs2943634, related to insulin resistance were associated with MetS (OR 1.16, 95%CI 1.02-1.32 and OR 0.88, 95% CI 0.79; 0.97, respectively). 23101478 2012
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.300 GeneticVariation disease BEFREE The rs1801278 G>A polymorphism of IRS-1 is associated with metabolic syndrome in healthy nondiabetic men. Modulation by cigarette smoking status. 21645940 2011
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.300 GeneticVariation disease BEFREE To assess the prevalence of IRS-1 Gly972Arg and GNB3 C825T polymorphisms in women with polycystic ovary syndrome (PCOS) and their relation to the metabolic syndrome and hyperandrogenaemia. 20170352 2010
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.300 AlteredExpression disease BEFREE The aim of this study was to assess the effect of functional ENPP1(ectoenzyme nucleotide pyrophosphate phosphodiesterase 1)/PC-1 (plasma cell antigen-1) and IRS-1 (insulin receptor substrate-1) polymorphisms influencing insulin receptor activity on liver damage in non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, whose progression is associated with the severity of insulin resistance. 20176643 2010
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.300 GeneticVariation disease BEFREE The polymorphisms PstI and MaeIII of INS, NsiI of INSR and Ala513Pro and Gly972Arg of IRS1 have been associated with metabolic syndrome; moreover, the products of these genes are functionally contiguous during insulin signaling. 18716398 2009
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.300 GeneticVariation disease BEFREE The most common IRS1 variant, a Gly --> Arg substitution at codon 972 (Arg972 IRS1), is more prevalent among subjects who have features of insulin resistance syndrome associated, or not, with type 2 diabetes in European populations. 15222685 2004
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.300 Biomarker disease BEFREE Carriers of Arg(972) IRS-1 displayed many features of the insulin resistance syndrome, including higher values for serum triglycerides (P < 0.01), total/high density lipoprotein cholesterol ratio (P < 0.01), free fatty acid levels (P < 0.04), systolic blood pressure (P < 0.04), microalbuminuria (P < 0.003), and intima-media thickness (P < 0.02). 12843189 2003
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.300 Biomarker disease RGD Molecular pathology in the obese spontaneous hypertensive Koletsky rat: a model of syndrome X. 10842668 1999