|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Deficiency in Androgen Receptor Aggravates the Depressive-Like Behaviors in Chronic Mild Stress Model of Depression.
|
31480771 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that the fact that OXT and testosterone appear to have opposite effects in neuropsychiatric disorders might be based upon a direct inhibition of AR on OXT transcription, which may provide a novel target for therapeutic strategies in depression.
|
28447621 |
2017 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The morphological changes of seminiferous tubules showed significant increases in depression and FST + fluoxetine groups, while AR expression showed significant decreases in depression, FST + fluoxetine and FST + GABA groups.
|
27108772 |
2017 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, genetic variants and the epigenetic profiles of the androgen receptor gene, well-known depression related genes, and HPA axis-related genes were shown to further interact with men's steroid secretion and thus may further contribute to the proposed male-specific pattern for depression.
|
28096796 |
2016 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Given that anxiety is widely reported as a precipitating factor in depression, studying the role of the androgen receptor in anxiety may give insights into the pathogenesis of major depressive disorder.
|
24269497 |
2014 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The relation between sex hormone levels, the androgen receptor CAGn-polymorphism and depression and mortality in older men in a community study.
|
23602133 |
2013 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The relation between sex hormone levels, the androgen receptor CAGn-polymorphism and depression and mortality in older men in a community study.
|
23602133 |
2013 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The two clinical samples had significantly longer AR CAG repeats and higher depression levels compared with the CS.
|
20808127 |
2011 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The two clinical samples had significantly longer AR CAG repeats and higher depression levels compared with the CS.
|
20808127 |
2011 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
While associations between somatic changes and sex hormone levels in aging men have been explored in many studies, the association of testosterone and estradiol with psychic symptoms other than depression and the role of the genetically determined CAG repeat (CAGn) polymorphism of the androgen receptor (AR) have received much less attention.
|
21883946 |
2011 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
While associations between somatic changes and sex hormone levels in aging men have been explored in many studies, the association of testosterone and estradiol with psychic symptoms other than depression and the role of the genetically determined CAG repeat (CAGn) polymorphism of the androgen receptor (AR) have received much less attention.
|
21883946 |
2011 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Neither anxiety (OR 1.0; 95% CI 0.40-2.4) nor depression (OR 1.1; 95% CI 0.20-6.4) were overrepresented in biochemically hypogonadal TGCC patients and no association between AR polymorphisms and EMD was found.
|
19656574 |
2010 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Neither anxiety (OR 1.0; 95% CI 0.40-2.4) nor depression (OR 1.1; 95% CI 0.20-6.4) were overrepresented in biochemically hypogonadal TGCC patients and no association between AR polymorphisms and EMD was found.
|
19656574 |
2010 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Among neurological alterations, a decreased AR function seems to be also involved in depression.
|
17945479 |
2008 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The relationship between depression and testosterone appears to partly depend upon the androgen receptor genotype of the patient, and in appropriate patients with low testosterone levels, testosterone substitution can increase positive mood and decrease negative mood.
|
17178554 |
2006 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To determine the prevalence of depression in a cohort of elderly men as assessed using a 30-item Geriatric Depression Scale (GDS) score and to describe the association between this score and sex steroids, androgen receptor (AR) polymorphism, and general health status.
|
15817010 |
2005 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
We assessed independent measures of hypothalamic-pituitary-gonadal axis functioning, i.e., total T level and androgen receptor (AR) CAG repeat length (CAG RL), a genetic trait marker associated with AR function; and depression (diagnosed by above-threshold score on the Center for Epidemiologic Studies-Depression Scale [CES-D]) in 1000 men (mean age = 62.6 years; SD = 8.3) who participated in the Massachusetts Male Aging Study.
|
11543741 |
2001 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Three of them are point mutations in the hormone-binding domain of the AR, the fourth mutation is a CAG-microsatellite depression in the N-terminus.
|
7971517 |
1994 |