AR, androgen receptor, 367

N. diseases: 854; N. variants: 163
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor
0.040 AlteredExpression phenotype BEFREE Loss of p(Ser2448)-mTOR staining was significantly linked to advanced stage (p = 0.0027), high-grade (p = 0.0045), nodal positive cancers (p = 0.0483), early tumor recurrence (p < 0.0001, independently from stage and grade, p = 0.0016), lack of Ets-related gene (ERG) fusion (p < 0.0001), reduced androgen receptor expression (p < 0.0001 each) and increased cell proliferation (p = 0.0092) in all cancers and in the subset of ERG-fusion-positive cancers. 22886792 2013
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor
0.040 AlteredExpression phenotype BEFREE This up-regulation in the AR levels is shown to increase sensitivity to low levels of androgen, leading to ligand-dependent downstream gene expression and tumor recurrence. 16210922 2005
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor
0.040 Biomarker phenotype BEFREE A critical question is whether the androgen receptor mediates recurrent tumor growth after androgen deprivation therapy. 11389051 2001
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor
0.040 GeneticVariation phenotype BEFREE High-level amplification of the AR gene was found in the recurrent tumor, whereas no evidence of amplification was found in the primary tumor. 9076469 1997