|
androgen independent prostate cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
NO may play a role in the development of androgen-independent prostate cancer via s-nitrosylation of the androgen receptor.
|
28326819 |
2017 |
|
androgen independent prostate cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The T887A mutated AR was frequently expressed in androgen independent prostate cancer (AIPC) patients.
|
28757136 |
2017 |
|
androgen independent prostate cancer
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The protein levels of Pim-1 and AR in the ADPC and AIPC groups were significantly different compared with the ADT group (P<0.01).
|
28599438 |
2017 |
|
androgen independent prostate cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular cloning of canine co-chaperone small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA) and investigation of its ability to suppress androgen receptor signalling in androgen-independent prostate cancer.
|
26346258 |
2015 |
|
androgen independent prostate cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nanobubbles carrying AR siRNA could be potentially used as gene vectors in combination with ultrasonic irradiation for the treatment of AIPC.
|
24798477 |
2014 |
|
androgen independent prostate cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of an anabolic selective androgen receptor modulator that actively induces death of androgen-independent prostate cancer cells.
|
24565564 |
2014 |
|
androgen independent prostate cancer
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we showed that the AR gene was upregulated by paired box 2 (PAX2) in androgen-independent prostate cancer.
|
25132193 |
2014 |
|
androgen independent prostate cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest that AR primes androgen-independent prostate cancer cells to DNA damage-induced apoptosis through the PIRH2-p53-p21 axis.
|
23159636 |
2013 |
|
androgen independent prostate cancer
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Effect of histone deacetylase and DNA methyltransferase inhibitors on the expression of the androgen receptor gene in androgen-independent prostate cancer cell lines.
|
23503510 |
2013 |
|
androgen independent prostate cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several studies indicate that NcoA4 localizes predominantly to the cytoplasm and affects ligand-binding specificity of the androgen receptor, which has important implications for androgen-independent prostate cancer.
|
22562579 |
2012 |
|
androgen independent prostate cancer
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Physalins A and B inhibit androgen-independent prostate cancer cell growth through activation of cell apoptosis and downregulation of androgen receptor expression.
|
21963499 |
2011 |
|
androgen independent prostate cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Results suggest that 17α-estradiol with less classic estrogenic activity is a potential therapeutic agent for androgen independent prostate cancer due to androgen receptor mutation.
|
21075385 |
2011 |
|
androgen independent prostate cancer
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To determine whether PPARγ ligands are equally effective at inhibiting AR activity in androgen-independent prostate cancer, we examined the effect of the PPARγ ligands ciglitazone and rosiglitazone on C4-2 cells, an androgen- independent derivative of the LNCaP cell line.
|
20932825 |
2010 |
|
androgen independent prostate cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-tumor effect of small interfering RNA targeting the androgen receptor in human androgen-independent prostate cancer cells.
|
20004643 |
2010 |
|
androgen independent prostate cancer
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recently, tyrosine kinase Ack1 has been shown to regulate AR activity by phosphorylating it at tyrosine 267 and this event was shown to be critical for AIPC growth.
|
20623637 |
2010 |
|
androgen independent prostate cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, SNARE-1 inhibits AR function by a mechanism that is distinct from clinically available antiandrogens, such that it might inform novel methods to block AR function in androgen-independent prostate cancer.
|
20068182 |
2010 |
|
androgen independent prostate cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular biology of androgen-independent prostate cancer: the role of the androgen receptor pathway.
|
19155198 |
2009 |
|
androgen independent prostate cancer
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we examined LEF1 expression in androgen-independent cancer as well as its regulation of androgen receptor (AR) expression, prostate cancer growth, and invasion in androgen-independent prostate cancer cells.
|
19351848 |
2009 |
|
androgen independent prostate cancer
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.
|
19632176 |
2009 |
|
androgen independent prostate cancer
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Together, these data support the notion that ET-1, via Src/PI-3K signaling, augments c-myc expression leading to enhanced AR expression in PC.
|
18623111 |
2009 |
|
androgen independent prostate cancer
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Five of those are dependent on the androgen receptor, which is present or over-expressed in androgen-independent prostate cancer tissue.
|
18262723 |
2008 |
|
androgen independent prostate cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that the AR status determines the sensitivity of prostate cancer cells to the apoptotic effects of TGF-beta1, thus providing a new insight into the mechanism via which TGF-beta cross-sections the AR axis toward the functional convergence of the two pathways in the development of androgen-independent prostate cancer.
|
18163430 |
2008 |
|
androgen independent prostate cancer
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of the androgen receptor (AR) occurs in androgen-independent prostate cancer and has been proposed as another mechanism promoting the development of androgen independence.
|
18479901 |
2008 |
|
androgen independent prostate cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
5alpha-androstane-3alpha,17beta-diol supports human prostate cancer cell survival and proliferation through androgen receptor-independent signaling pathways: implication of androgen-independent prostate cancer progression.
|
18320593 |
2008 |
|
androgen independent prostate cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that intracellular control of AR expression levels through the natural AR promoter might be needed for determining AR function in androgen-independent prostate cancer (AIPC) PC-3 cells.
|
17334587 |
2007 |