Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.070 AlteredExpression disease BEFREE Through microarray analysis of GSE27382 and GSE23343, ISL1 was found to be downregulated in T2DM. 30341898 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation disease BEFREE Variants in USF1, ABCC8, ISL1 and KCNJ11 showed nominal association, while haplotypes in these genes were significantly associated. rs3812704 upstream of NEUROG3 significantly increased risk for type 2 diabetes in normal-weight/lean subjects (OR=1.68 (95%CI 1.25-2.24), P=4.9 × 10(-4)). 21814221 2011
Diabetes Mellitus, Non-Insulin-Dependent
0.070 AlteredExpression disease BEFREE ISL1 expression is up-regulated at the mRNA level in type 2 diabetes (db/db mouse model) but down-regulated by dexamethasone in rat insulinoma cells. 19619559 2009
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation disease BEFREE However, in French Caucasian morbidly obese subjects, the Isl1-47A-->G SNP may modulate the risk for type 2 diabetes and may increase body weight in diabetic morbidly obese subjects. 11978668 2002
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation disease BEFREE Although Isl-1 is not a common predisposing gene for Japanese type 2 diabetes, the mutation in this gene may be a rare cause of diabetes in isolated families. 10969846 2000
Diabetes Mellitus, Non-Insulin-Dependent
0.070 Biomarker disease BEFREE To evaluate this gene in non-insulin-dependent diabetes mellitus (NIDDM), a full-length human Isl-1 cDNA was isolated and the genomic structure was characterized. 7789634 1995
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation disease BEFREE The simple sequence repeat polymorphism at the Isl-1 locus was used to evaluate mutations in this gene as a possible contributor to the pathogenesis of NIDDM. 7912209 1994