|
Abdominal aortic atherosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The GPIIIa Pl(A) polymorphism in the progression of abdominal aortic atherosclerosis.
|
10525125 |
1999 |
|
Abnormal behavior
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The integrin-β 3 subunit gene (ITGB3) gene at 17q21.32 has been implicated in psychiatric disorders.
|
23860687 |
2013 |
|
Acute Cerebrovascular Accidents
|
0.300 |
Biomarker
|
disease |
CTD_human |
Depressed platelet status in an elderly patient with hemorrhagic stroke after thrombolysis for acute myocardial infarction. GUSTO-III Investigators.
|
9445356 |
1998 |
|
Acute Coronary Syndrome
|
0.320 |
Biomarker
|
disease |
CTD_human |
Glycoprotein IIIA gene (PlA) polymorphism and aspirin resistance: is there any correlation?
|
15840736 |
2005 |
|
Acute Coronary Syndrome
|
0.320 |
GeneticVariation
|
disease |
LHGDN |
Platelet glycoprotein IIb HPA-3 polymorphism and acute coronary syndromes.
|
17561290 |
2008 |
|
Acute Coronary Syndrome
|
0.320 |
GeneticVariation
|
disease |
LHGDN |
Glycoprotein IIIA gene (PlA) polymorphism and aspirin resistance: is there any correlation?
|
15840736 |
2005 |
|
Acute myocardial infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Multinominal logistic-regression analysis showed gene-gene (GP1BA 1018C/T with GP1BA VNTR and ITGA2 807C/T with ITGB3 1565T/C polymorphisms) and gene-environment interactions (gene polymorphisms with smoking) operating in the occurrence of AMI in young.
|
22535530 |
2012 |
|
Acute myocardial infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
In a small case-control study, evidence has been presented that the PlA2 allele of the platelet glycoprotein GPIIIa PlA/A2 gene polymorphism might be an independent risk factor for acute myocardial infarction (MI).
|
9716139 |
1998 |
|
Acute myocardial infarction
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our results indicated that inhibiting integrin β-3 reduced attachment, retention and therapeutic benefits of human cardiospheres in mice with acute myocardial infarction.
|
29024385 |
2018 |
|
Acute Undifferentiated Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TRIM62 loss was associated with altered expression of proteins involved in leukemia stem cell homeostasis (β-catenin and Notch), cell motility, and adhesion (integrin-β3, ras-related C3 botulinum toxin substrate [RAC], and fibronectin), hypoxia (Hypoxia-inducible factor 1-alpha [HIF1α], egl-9 family hypoxia-inducible factor 1 [Egln1], and glucose-regulated protein, 78 kDa [GRP78]), and apoptosis (B-cell lymphoma-extra large (BclXL) and caspase 9).
|
25248926 |
2015 |
|
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Expression of ITGB3 and BCL-2 in lung adenocarcinoma and adenocarcinoma cell line showed heterogeneity that expression in trailing edge was higher than that of trailing edge, which may play an important role in promoting tumor lymph node metastasis and vascular invasion, and provides a new research direction for exploration of lung adenocarcinoma metastasis mechanism.
|
25066397 |
2014 |
|
Adenocarcinoma
|
0.030 |
Biomarker
|
group |
BEFREE |
External validation suggests Integrin beta 3 as prognostic biomarker in serous ovarian adenocarcinomas.
|
19775429 |
2009 |
|
Adenocarcinoma
|
0.030 |
Biomarker
|
group |
LHGDN |
According to our results, the 4 biomarkers CLU, ITGB3, PRAME and CAPG may be used as prognostic factors for patients with stage III serous ovarian adenocarcinomas.
|
18709641 |
2008 |
|
Adult Fibrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results identify a novel mechano-sensitive response in human fibrosarcoma that utilizes PAK1 as a signaling player positioned downstream of integrin β3.
|
31781560 |
2019 |
|
Adult Myelodysplastic Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, flow cytometry identified multiple immunophenotypic abnormalities on platelets of myelodysplastic syndrome patients, including altered light scatter characteristics, over-and under expression of specific platelet glycoproteins and asynchronous expression of CD34; decreased expression of CD36 (n = 5), CD42a (n = 1) and CD61 (n = 2), together with reactivity for CD34 (n = 1) were only observed among myelodysplastic syndrome cases, while other alterations were also found in other platelet disorders.
|
22271903 |
2012 |
|
Adult Soft Tissue Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with grade 1 (G1) soft tissue sarcoma (n = 3) presented with significantly lower levels of platelet (CD61-positive) microvesicles than patients with G3 soft tissue sarcoma (n = 9) (p = 0.0150).
|
28784104 |
2017 |
|
Allergic sensitization
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Variation in ITGB3 was strongly associated with susceptibility to bronchial hyperresponsiveness and protection from allergic sensitization to mold allergens in this population.
|
15817799 |
2005 |
|
Allergic sensitization
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that genetic variation in ITGB3 contributes to asthma susceptibility and allergic sensitization, and that the effects of this gene begin early in life.
|
17556058 |
2007 |
|
Alloimmunisation
|
0.030 |
Biomarker
|
disease |
BEFREE |
This study shows that the GST/N-terminal GPIIIa fusion proteins contain conformational epitopes that mimic those involved in alloimmunization, and that regions other than the amino terminal 66 amino acids of GPIIIa are not likely to contain or be required for the development of functional PlA1 epitopes.
|
7519475 |
1994 |
|
Alloimmunisation
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Among central Europeans polymorphisms of GPIIIa, GPIb, GPIIb, and GPIa named human platelet antigen-1 (HPA-1), -2, -3, and -5 are the clinically most relevant systems in which alloimmunization occurs.
|
9684730 |
1998 |
|
Alloimmunisation
|
0.030 |
Biomarker
|
disease |
BEFREE |
Maternal DRB1*1501, DQA1*0102, DQB1*0602 haplotype in fetomaternal alloimmunization against human platelet alloantigen HPA-6b (GPIIIa-Gln489).
|
9271820 |
1997 |
|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our analysis identifies a region in the ITGB3 gene that potentially harbors disease susceptibility loci for Alzheimer's disease.
|
28318110 |
2017 |
|
Anemia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Angina, Unstable
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Platelet glycoprotein IIb HPA-3 polymorphism and acute coronary syndromes.
|
17561290 |
2008 |
|
Anoxia
|
0.010 |
AlteredExpression
|
phenotype |
LHGDN |
Cleavage of integrin by mu-calpain during hypoxia in human endometrial cells.
|
15663601 |
2004 |