ITGB3, integrin subunit beta 3, 3690

N. diseases: 260; N. variants: 44
Disease: Autistic Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.370 GeneticVariation disease BEFREE ITGB3 haplotypes are significantly associated with autism (HBAT, global P=0.038). 21102624 2011
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.370 Biomarker disease BEFREE Studies point to possible links between autism and two serotonin related genes: SLC6A4 and ITGB3 with a sex-specific genetic effect and interaction between the genes. 19588468 2010
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.370 Biomarker disease BEFREE No markers in ITGA3, ITGA6, ITGAV and ITGB3 were found to be associated with autism. 21182210 2010
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.370 GeneticVariation disease BEFREE We report a significant main effect of the HTR5A gene in autism (P = 0.0088), and a significant three-locus model comprising a synergistic interaction between the ITGB3 and SLC6A4 genes with an additive effect of HTR5A (P < 0.0010). 17203304 2007
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.370 Biomarker disease CTD_human We report a significant main effect of the HTR5A gene in autism (P = 0.0088), and a significant three-locus model comprising a synergistic interaction between the ITGB3 and SLC6A4 genes with an additive effect of HTR5A (P < 0.0010). 17203304 2007
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.370 GeneticVariation disease BEFREE Analyzing four markers in SLC6A4 and four markers in ITGB3 in 117 white family triads with autism and using sex of the proband as a PC, we found significant interaction between two markers--rs1042173 in SLC6A4 and rs3809865 in ITGB3. 17999363 2007
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.370 AlteredExpression disease LHGDN We report a significant main effect of the HTR5A gene in autism (P = 0.0088), and a significant three-locus model comprising a synergistic interaction between the ITGB3 and SLC6A4 genes with an additive effect of HTR5A (P < 0.0010). 17203304 2007
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.370 GeneticVariation disease LHGDN Lastly, we show that a coding variant of ITGB3 is associated with autism susceptibility in a large multiplex sample (P = 0.00082), and that this variation has different effects in males and females (P = 0.0018). 16724005 2006
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.370 Biomarker disease CTD_human Lastly, we show that a coding variant of ITGB3 is associated with autism susceptibility in a large multiplex sample (P = 0.00082), and that this variation has different effects in males and females (P = 0.0018). 16724005 2006
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.370 Biomarker disease CTD_human We also show preliminary evidence that genotypes at the ITGB3 and SLC6A4 loci may interact to affect autism susceptibility (P=0.033). 16721604 2006
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.370 GeneticVariation disease BEFREE We also show preliminary evidence that genotypes at the ITGB3 and SLC6A4 loci may interact to affect autism susceptibility (P=0.033). 16721604 2006
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.370 GeneticVariation disease BEFREE Lastly, we show that a coding variant of ITGB3 is associated with autism susceptibility in a large multiplex sample (P = 0.00082), and that this variation has different effects in males and females (P = 0.0018). 16724005 2006