ITGB3, integrin subunit beta 3, 3690

N. diseases: 260; N. variants: 44
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010072
Disease: Coronary Thrombosis
Coronary Thrombosis
0.350 GeneticVariation disease BEFREE A common isoform of integrin β3, Leu33Pro is associated with enhanced platelet function and increased risk for coronary thrombosis and stroke, although these findings remain controversial. 24695082 2014
CUI: C0010072
Disease: Coronary Thrombosis
Coronary Thrombosis
0.350 GeneticVariation disease BEFREE Previous studies showed an association between the GPIIIa Pl(A1/A2) polymorphism and coronary thrombosis, while there is only contrasting evidence about its role in stroke. 17278970 2007
CUI: C0010072
Disease: Coronary Thrombosis
Coronary Thrombosis
0.350 GeneticVariation disease BEFREE In view of previous studies linking the presence of the PlA2 allele of GPIIIa to a higher risk for coronary artery thrombosis, our data have physiologic relevance. 15166939 2004
CUI: C0010072
Disease: Coronary Thrombosis
Coronary Thrombosis
0.350 GeneticVariation disease BEFREE The PlA polymorphism of the gene for GPIIIa (beta3 integrin) has been suggested to play an important role in the progression of coronary artery disease (CAD) and in coronary thrombosis. 11257275 2001
CUI: C0010072
Disease: Coronary Thrombosis
Coronary Thrombosis
0.350 GeneticVariation disease BEFREE Our results suggest that the A2 allele of the Pl(A1/A2) polymorphism of GPIIIa is a major risk factor of coronary thrombosis and may be one important predictor of SCD in early middle age. 11028489 2000
CUI: C0010072
Disease: Coronary Thrombosis
Coronary Thrombosis
0.350 Biomarker disease CTD_human A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. 8598867 1996