|
Failure to Thrive
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Microcephaly
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Seizures
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Feeding difficulties
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Hypoplasia of scrotum
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Cerebellar atrophy
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Penis agenesis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Impaired smooth pursuit
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Generalized hypotonia
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormal glycosylation
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Epidermodysplasia Verruciformis
|
0.020 |
Biomarker
|
disease |
BEFREE |
This data suggest that the TMC-PCR assay may be suitable for routine diagnostic screening from patient suspected EV infection.
|
21714898 |
2011 |
|
Anthrax disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Altogether, the results suggest that CpG or Poly I:C adjuvanted, PA-loaded TMC nanoparticles could be used as an effective, non-toxic, second generation subunit-vaccine candidate against anthrax.
|
29616046 |
2018 |
|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using an institutional generated whole exome data set of 132 samples of Indian origin, we demonstrate that TMC-SNPdb could deplete 42, 33 and 28% false positive somatic events post dbSNP depletion in Indian origin tongue, gallbladder, and cervical cancer samples, respectively.
|
27402678 |
2016 |
|
IGA Glomerulonephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IgA production from IgAN-TMCs was inhibited by APRIL neutralization antibody or TACI blocking antibody, and enhanced by co-treatment of APRIL and CpG-ODN.
|
31088610 |
2019 |
|
Herpes Simplex Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Targeting STT3A-oligosaccharyltransferase with NGI-1 causes herpes simplex virus 1 dysfunction.
|
30811219 |
2019 |
|
African Trypanosomiasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>Trypanosoma brucei</i> causes African trypanosomiasis and contains three full-length oligosaccharyltransferase (OST) genes; two of which, <i>Tb</i>STT3A and <i>Tb</i>STT3B, are expressed in the bloodstream form of the parasite.
|
28928222 |
2017 |
|
Follicular thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Four genes (DDIT3, ARG2, ITM1, and C1orf24) differed between the two classes FTC and FTA, and a linear combination of expression levels distinguished FTC from FTA with an estimated predictive accuracy of 0.83.
|
15085203 |
2004 |
|
Mucoepidermoid Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The second patient with mucoepidermoid carcinoma of the parotic gland received TMC as first-line therapy with rapid disease progression.
|
31424693 |
2020 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using an institutional generated whole exome data set of 132 samples of Indian origin, we demonstrate that TMC-SNPdb could deplete 42, 33 and 28% false positive somatic events post dbSNP depletion in Indian origin tongue, gallbladder, and cervical cancer samples, respectively.
|
27402678 |
2016 |
|
Congenital bilateral aplasia of vas deferens
|
0.010 |
Biomarker
|
disease |
BEFREE |
BMI: body mass index; SA: semen analysis; AR: acrosome reaction; DFI: DNA fragmentation index; GAM: generalized additive model; TSC: total sperm count; TMC: total motile sperm count; IUI: intrauterine insemination; SCSA: sperm chromatin structure assay; SD: standard deviation; IQR: interquartile range; CBAVD: congenital bilateral absence of vas deferens; NEQAS: national external quality assessment service; HTF: human tubal fluid; HSA: human serum albumin.
|
30033774 |
2018 |
|
Squamous cell carcinoma of skin
|
0.010 |
Biomarker
|
disease |
BEFREE |
To clarify the correlation between SNPs in both TMC genes and cSCC development in RTRs, integrated investigations of large cohorts including both RTRs and immunocompetent individuals with consideration of cSCC status, SNP genotype and human papillomavirus status might be necessary.
|
26227733 |
2015 |
|
Seizures, Focal
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Finally, TMC-120A and TMC-120B were investigated in a mouse model of drug-resistant focal seizures.
|
31731399 |
2019 |
|
Human immunodeficiency virus (HIV) II infection category B1
|
0.010 |
Biomarker
|
disease |
BEFREE |
TMC-125, DPC-083)] against those HIV strains that are resistant to the "first" generation NNRTIs, or (iii) as in the case of PIs, a different, nonpeptidic scaffold [i.e. cyclic urea (mozenavir), 4-hydroxy-2-pyrone (tipranavir)].
|
12084468 |
2002 |
|
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using an institutional generated whole exome data set of 132 samples of Indian origin, we demonstrate that TMC-SNPdb could deplete 42, 33 and 28% false positive somatic events post dbSNP depletion in Indian origin tongue, gallbladder, and cervical cancer samples, respectively.
|
27402678 |
2016 |
|
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of β-catenin and STT3A/B in colon cancer tissues was initially detected by immunohistochemistry, followed by correlation analyses of the survival rate with the expression of β-catenin and STT3A/B as well as identification of the interaction between β-catenin and STT3A/B.
|
31812723 |
2020 |