|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of inosine triphosphate pyrophosphatase (rs1127354 and rs6051702) and interferon lambda 4 (IFLN4) (rs12979860) are indicators of anemia and/or sustained virological response (SVR) in patients with chronic hepatitis C on ribavirin/interferon.
|
31359493 |
2020 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the current study, 100 Iranian patients with chronic hepatitis C were examined and genotyped for ITPA rs1127354 and rs7270101 gene polymorphisms.
|
29660762 |
2018 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ITPA gene variation and ribavirin-induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin.
|
28128521 |
2017 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Few data are available concerning the roles of polymorphisms of inosine triphosphatase (ITPA) gene and ribavirin (RBV) transporter genes in the prediction of RBV-induced anaemia among Egyptians with chronic hepatitis C (CHC).
|
28543275 |
2017 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the inosine triphosphatase (ITPA) gene is associated with anemia induced by peg-interferon (PEG-IFN) plus ribavirin (RBV) treatment for patients with chronic hepatitis C virus (HCV) infection.
|
27822709 |
2017 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Impact of ITPA gene polymorphisms on the risk of ribavirin-induced haemolytic anaemia using interferon-free antivirals for chronic hepatitis C.
|
28198349 |
2017 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ITPA gene polymorphism (94C>A) effects on ribavirin-induced anemia during therapy in Egyptian patients with chronic hepatitis C.
|
28480960 |
2017 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ITPA polymorphisms have been associated with protection against ribavirin-induced anemia in chronic hepatitis C (HCV) patients.
|
25968438 |
2015 |
|
Hepatitis C, Chronic
|
0.200 |
Biomarker
|
disease |
BEFREE |
Genetic polymorphisms in the inosine triphosphatase (ITPA) gene have been associated with the protection from early ribavirin(RBV)-induced hemolytic anemia among patients with chronic hepatitis C virus (HCV) infection.
|
26441325 |
2015 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These findings demonstrate a novel ribavirin-like association between polymorphisms at ITPA and treatment efficacy in chronic hepatitis C mediated by reduced relapse risk.
|
24519039 |
2014 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The newly identified association between RBV serum levels and SLC28A2 rs11854484 genotype, as well as the replicated association of ITPA and SLC28A3 genetic polymorphisms with RBV-induced anemia and treatment response, may support individualized treatment of chronic hepatitis C and warrant further investigation in larger studies.
|
23195617 |
2013 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A formula to estimate the optimal dosage of ribavirin for the treatment of chronic hepatitis C: influence of ITPA polymorphisms.
|
22809728 |
2012 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Several factors including ITPA polymorphism influence ribavirin-induced anemia in chronic hepatitis C.
|
23139603 |
2012 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The use of noninvasive tools to measure liver fibrosis (i.e., elastometry) and pharmacogenomics (testing for IL28B and perhaps ITPA polymorphisms), along with consideration of early viral kinetics to guide length and drugs needed could help to individualize and improve the cost effectiveness of therapeutic decisions using DAA in HIV-infected patients with chronic hepatitis C.
|
22760653 |
2012 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism of the inosine triphosphate pyrophosphatase gene predicts ribavirin-induced anemia in chronic hepatitis C patients.
|
22052220 |
2012 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Gene expression profiles associated with anaemia and ITPA genotypes in patients with chronic hepatitis C (CH-C).
|
22571903 |
2012 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
An association between a single nucleotide polymorphism (SNP) in the inosine triphosphate pyrophosphatase (ITPA) gene and reduction of hemoglobin during peg-interferon plus ribavirin combination therapy for patients with chronic hepatitis C virus (HCV) infection has been reported.
|
21503919 |
2011 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C.
|
21659334 |
2011 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Impact of inosine triphosphatase gene variants on the risk of anemia in HIV/hepatitis C virus-coinfected patients treated for chronic hepatitis C.
|
22028438 |
2011 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C.
|
20173735 |
2010 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C.
|
20173735 |
2010 |
|
Hepatitis C, Chronic
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C.
|
20173735 |
2010 |